FOXO proteins are transcription factors that are involved in numerous physiological
processes and in various pathological conditions, including cardiovascular disease, cancer …

Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …

Cancer constitutes a grave problem nowadays in view of the fact that it has become one of
the main causes of death worldwide. Poor clinical prognosis is presumably due to cancer …

Rapid proliferation is a hallmark of cancer associated with sensitivity to therapeutics that
cause DNA replication stress (RS). Many tumors exhibit drug resistance, however, via …

The global increase in lifespan noted not only in developed nations, but also in large
developing countries parallels an observed increase in a significant number of non …

Background Globally, lung cancer is the leading cause of cancer associated mortalities. The
current conventional chemotherapy remains the preferred treatment option for lung cancer …

FOXO family of proteins are transcription factors involved in many physiological and
pathological processes including cellular homeostasis, stem cell maintenance, cancer …

Identification of multidrug (MDR) efflux transporters that belong to the ATP-Binding Cassette
(ABC) superfamily, represented an important breakthrough for understanding cancer …

Sirtuins are a vast family of histone deacetylases, which are NAD+ dependent enzymes,
consisting of seven members, namely SIRT 1, SIRT 6 and SIRT 7 located within the nucleus …

Almost three million individuals suffer from multiple sclerosis (MS) throughout the world, a
demyelinating disease in the nervous system with increased prevalence over the last five …