As a non-canonical fibroblast growth factor, fibroblast growth factor 21 (FGF21) functions as
an endocrine hormone that signals to distinct targets throughout the body. Interest in …

The rising global prevalence of obesity, metabolic syndrome, and type 2 diabetes has driven
a sharp increase in non-alcoholic fatty liver disease (NAFLD), characterized by excessive fat …

Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth
factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very …

Fibroblast growth factor (FGF) 21 is a recently recognized metabolic regulator that evokes
interest due to its beneficial action of maintaining whole-body energy balance and protecting …

Carbohydrate response element-binding protein (ChREBP) plays an important role in the
development of type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease, as well …

The liking and selective ingestion of palatable foods—including sweets—is biologically
controlled, and dysfunction of this regulation may promote unhealthy eating, obesity, and …

Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of pathologies ranging
from uncomplicated hepatic fat accumulation to a state of lobular inflammation and …

Fasting and starvation were common occurrences during human evolution and accordingly
have been an important environmental factor shaping human energy metabolism. Humans …

Summary Fibroblast growth factor 21 (FGF21) is an endocrine hormone produced by the
liver that regulates nutrient and metabolic homeostasis. FGF21 production is increased in …

Fibroblast growth factor 21 (FGF21) is a protein highly synthesized in the liver that exerts
paracrine and endocrine control of many aspects of energy homeostasis in multiple tissues …