Rhabdomyosarcoma (RMS) is a malignant tumor of mesenchymal origin thought to arise
from cells committed to a skeletal muscle lineage. With approximately 250 cases diagnosed …

Beckwith–Wiedemann syndrome (BWS) is a clinically heterogeneous overgrowth syndrome
associated with an increased risk for embryonal tumor development. BWS provides an ideal …

25–30% of families fulfilling the criteria for hereditary diffuse gastric cancer have germline
mutations of the CDH1 (E-cadherin) gene. In light of new data and advancement of …

Acinar cell carcinomas (ACCs) are rare malignant tumors of the exocrine pancreas. The
specific molecular alterations that characterize ACCs have not yet been elucidated. ACCs …

Pancreatoblastomas are unusual malignant neoplasms of the pediatric pancreas that may
also rarely affect adults. The molecular pathogenesis of pancreatoblastomas is unknown …

Immunohistochemical analysis of p57 expression and molecular genotyping accurately
subclassify molar specimens into complete hydatidiform mole (CHM) and partial …

Introduction The Li–Fraumeni Syndrome is caused by a germline TP53 mutation and is
associated with a high risk of breast cancer at young ages. Basal (triple negative) breast …

Silver-Russell syndrome (SRS) is characterized by pre-and postnatal growth failure and
other dysmorphic features. The syndrome is genetically heterogenous, but maternal …

An understanding of the role of inherited cancer predisposition syndromes in pediatric tumor
diagnoses continues to develop as more information is learned through the application of …

A palpable mass in the abdomen of a child is a serious finding. It requires urgent attention to
determine if it is malignant and if there is compression of vital organs or internal …