The phase separation occurring in a system of mutually interacting proteins that can bind on
specific sites of a chromatin fiber is investigated here. This is achieved by means of …

It is generally agreed that the nuclei of eukaryotic cells at interphase are partitioned into
disjointed territories, with distinct regions occupied by certain chromosomes. However, the …

Within the confines of a densely populated cell nucleus, chromatin undergoes intricate
folding, forming loops, domains, and compartments under the governance of topological …

Human chromosomes have a complex 3D spatial organization in the cell nucleus, which
comprises a hierarchy of physical interactions across genomic scales. Such an architecture …

Bacterial genomes are partitioned into kilobases long domains that are topologically
independent from each other, meaning that change of DNA superhelicity in one domain …

The kinetics of protein motion on DNA is linked inextricably with the topology of the polymer
itself. Collapsed conformations of chromatin, characterized by long loops which bring distant …

Chromosomes have a complex spatial organization in the cell nucleus (1, 2), as revealed by
new high-throughput technologies (3, 4). Such an organization serves vital functional …

A generative model provides a framework for applying Bayesian methods to complex
experimentaldata like microscope images by describing them as a statistical probability …

The central theme of the dissertation is to understand physical principles underlying the
dynamical self-organization of the genome in the cell across different length and time scales …

Chromatin architecture plays an important role in gene regulation. Recent advances in
super-resolution microscopy have made it possible to measure chromatin 3D structure and …