[HTML][HTML] Development of novel follicular thyroid cancer models which progress to poorly differentiated and anaplastic thyroid cancer
CO Caperton, LA Jolly, N Massoll, AJ Bauer, AT Franco - Cancers, 2021 - mdpi.com
Simple Summary Advancements in thyroid cancer are dependent on the availability of
experimental models allowing for investigation in the laboratory setting. Here, we detail the …
experimental models allowing for investigation in the laboratory setting. Here, we detail the …
Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) plays an oncogenic role in thyroid carcinoma by activating the AKT and ERK1/2 signaling pathway
C Peng, C Zhang, W Yu, L Li, Z Zhang… - Current Cancer Drug …, 2023 - ingentaconnect.com
Background: Thyroid carcinoma (TC) is a common malignant tumor in human and its
incidence has been increasing in recent years. Studies have shown that receptor type …
incidence has been increasing in recent years. Studies have shown that receptor type …
[HTML][HTML] Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells
J Xu, D Xue, Y Li, J Zhou, H Chen, L Fan - Heliyon, 2024 - cell.com
Abstract Background Anaplastic Thyroid Carcinoma (ATC) is a rare and deadly malignant
tumor in humans. It is prone to developing resistance to radiotherapy and chemotherapy …
tumor in humans. It is prone to developing resistance to radiotherapy and chemotherapy …
[HTML][HTML] Modulatory role of miRNAs in thyroid and breast cancer progression and insights into their therapeutic manipulation
R Ahmed, S Samanta, J Banerjee, SS Kar… - Current Research in …, 2022 - Elsevier
Over the past few decades, thyroid cancer has become one of the most common types of
endocrine cancer, contributing to an increase in prevalence. In the year 2020, there were …
endocrine cancer, contributing to an increase in prevalence. In the year 2020, there were …
Vemurafenib activates the sonic hedgehog pathway and promotes thyroid cancer stem cell self-renewal
Y Lu, Y Zhao, P Liu, X Xu - Endocrine-Related Cancer, 2023 - erc.bioscientifica.com
B-Raf kinase inhibitors such as vemurafenib (PLX4032) and dabrafenib have limited
therapeutic efficacy on BRAF-mutated thyroid cancer. Cancer stem cells (CSCs) play …
therapeutic efficacy on BRAF-mutated thyroid cancer. Cancer stem cells (CSCs) play …
[HTML][HTML] Update on current diagnosis and management of anaplastic thyroid carcinoma
ET Pavlidis, IN Galanis, TE Pavlidis - World Journal of Clinical …, 2023 - ncbi.nlm.nih.gov
Well-differentiated thyroid carcinoma has a favorable prognosis with a 5-year survival rate of
over 95%. However, the undifferentiated or anaplastic type accounting for< 0.2%, usually in …
over 95%. However, the undifferentiated or anaplastic type accounting for< 0.2%, usually in …
[HTML][HTML] RBX1 regulates PKM alternative splicing to facilitate anaplastic thyroid carcinoma metastasis and aerobic glycolysis by destroying the SMAR1/HDAC6 …
D Xu, J Yu, Y Yang, Y Du, H Lu, S Zhang, Q Feng… - Cell & Bioscience, 2023 - Springer
Background Anaplastic thyroid carcinoma (ATC) is one of the most aggressive
malignancies, frequently accompanied by metastasis and aerobic glycolysis. Cancer cells …
malignancies, frequently accompanied by metastasis and aerobic glycolysis. Cancer cells …
PFKFB3 facilitates cell proliferation and migration in anaplastic thyroid carcinoma via the WNT/β‐catenin signaling pathway
J Deng, Y Cheng, H Li, X He, S Yu, J Ma, X Li, J Chen… - Endocrine, 2024 - Springer
Purpose Despite the involvement of 6‐phosphofructo‐2‐kinase/fructose‐2, 6‐
biphosphatase3 (PFKFB3) in the proliferation and metastasis of diverse tumor types, its …
biphosphatase3 (PFKFB3) in the proliferation and metastasis of diverse tumor types, its …
[HTML][HTML] The TUSC2 tumour suppressor inhibits the malignant phenotype of human thyroid cancer cells via SMAC/DIABLO protein
RM Mariniello, F Maria Orlandella… - International Journal of …, 2020 - mdpi.com
Thyroid carcinoma is the most common endocrine cancer and includes different forms.
Among these, anaplastic thyroid carcinoma (ATC) is the rarest but the most lethal subtype …
Among these, anaplastic thyroid carcinoma (ATC) is the rarest but the most lethal subtype …
[HTML][HTML] BI-847325, a selective dual MEK and Aurora kinases inhibitor, reduces aggressive behavior of anaplastic thyroid carcinoma on an in vitro three-dimensional …
Background Anaplastic thyroid carcinoma (ATC) is the most aggressive subtype of thyroid
cancer. In this study, we used a three-dimensional in vitro system to evaluate the effect of a …
cancer. In this study, we used a three-dimensional in vitro system to evaluate the effect of a …