Abnormal blood and lymphatic vessels create a hostile tumor microenvironment
characterized by hypoxia, low pH, and elevated interstitial fluid pressure. These …

The pulmonary vasculature has been frequently overlooked in acute and chronic lung
diseases, such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), and …

Pulmonary fibrosis results from dysregulated lung repair and involves multiple cell types.
The role of endothelial cells (EC) in lung fibrosis is poorly understood. Using single cell RNA …

Global climate change has a significant effect on extreme environments and a profound
influence on species survival. However, little is known of the genome-wide pattern of …

Blood perfusion in tumors can be significantly lower than that in the surrounding normal
tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion …

The mutual and interdependent interaction between tumor and its microenvironment is a
crucial topic in cancer research. Recently, it was reported that targeting stromal events could …

Background: Host immunity has critical roles in tumour surveillance. Tertiary lymphoid
organs (TLOs) are induced in various inflamed tissues. The aim of this study was to …

A functional vascular system is indispensable for drug delivery and fundamental for
responsiveness of the tumour microenvironment to such medication. At the same time, the …

Notwithstanding cancer patients benefit from a plethora of therapeutic alternatives, drug
resistance remains a critical hurdle. Indeed, the high mortality rate is associated with …

Abnormal angiogenesis stands for one of the most striking manifestations of malignant
tumor. The pathologically and structurally abnormal tumor vasculature facilitates a hostile …