Normalizing function of tumor vessels: progress, opportunities, and challenges
Abnormal blood and lymphatic vessels create a hostile tumor microenvironment
characterized by hypoxia, low pH, and elevated interstitial fluid pressure. These …
characterized by hypoxia, low pH, and elevated interstitial fluid pressure. These …
[PDF][PDF] The vascular perspective on acute and chronic lung disease
I Borek, A Birnhuber, NF Voelkel… - Journal of Clinical …, 2023 - Am Soc Clin Investig
The pulmonary vasculature has been frequently overlooked in acute and chronic lung
diseases, such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), and …
diseases, such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), and …
Lung endothelial cells regulate pulmonary fibrosis through FOXF1/R-Ras signaling
Pulmonary fibrosis results from dysregulated lung repair and involves multiple cell types.
The role of endothelial cells (EC) in lung fibrosis is poorly understood. Using single cell RNA …
The role of endothelial cells (EC) in lung fibrosis is poorly understood. Using single cell RNA …
Whole-genome sequencing of native sheep provides insights into rapid adaptations to extreme environments
JI Yang, WR Li, FH Lv, SG He, SL Tian… - Molecular biology …, 2016 - academic.oup.com
Global climate change has a significant effect on extreme environments and a profound
influence on species survival. However, little is known of the genome-wide pattern of …
influence on species survival. However, little is known of the genome-wide pattern of …
Combining two strategies to improve perfusion and drug delivery in solid tumors
T Stylianopoulos, RK Jain - Proceedings of the National …, 2013 - National Acad Sciences
Blood perfusion in tumors can be significantly lower than that in the surrounding normal
tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion …
tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion …
Tumor and its microenvironment: a synergistic interplay
The mutual and interdependent interaction between tumor and its microenvironment is a
crucial topic in cancer research. Recently, it was reported that targeting stromal events could …
crucial topic in cancer research. Recently, it was reported that targeting stromal events could …
Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer
N Hiraoka, Y Ino, R Yamazaki-Itoh, Y Kanai… - British journal of …, 2015 - nature.com
Background: Host immunity has critical roles in tumour surveillance. Tertiary lymphoid
organs (TLOs) are induced in various inflamed tissues. The aim of this study was to …
organs (TLOs) are induced in various inflamed tissues. The aim of this study was to …
Vascular normalisation as the stepping stone into tumour microenvironment transformation
AL Magnussen, IG Mills - British journal of cancer, 2021 - nature.com
A functional vascular system is indispensable for drug delivery and fundamental for
responsiveness of the tumour microenvironment to such medication. At the same time, the …
responsiveness of the tumour microenvironment to such medication. At the same time, the …
Meeting the challenge of targeting cancer stem cells
Notwithstanding cancer patients benefit from a plethora of therapeutic alternatives, drug
resistance remains a critical hurdle. Indeed, the high mortality rate is associated with …
resistance remains a critical hurdle. Indeed, the high mortality rate is associated with …
Emerging nanotechnological approaches to regulating tumor vasculature for cancer therapy
Abnormal angiogenesis stands for one of the most striking manifestations of malignant
tumor. The pathologically and structurally abnormal tumor vasculature facilitates a hostile …
tumor. The pathologically and structurally abnormal tumor vasculature facilitates a hostile …