Living organisms are continuously exposed to a myriad of DNA damaging agents that can
impact health and modulate disease‐states. However, robust DNA repair and damage …

The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an
apical activator of the DNA damage response in the face of DNA double-strand breaks …

Unresectable glioblastoma (GBM) cells in the invading tumor edge can act as seeds for
recurrence. The molecular and phenotypic properties of these cells remain elusive. Here, we …

Genomic instability is a characteristic of most cancer cells. It is an increased tendency of
genome alteration during cell division. Cancer frequently results from damage to multiple …

Extensive research in the past decade has identified innate immune recognition receptors
and intracellular signaling pathways that culminate in inflammatory responses. Besides its …

Stem cells are characterized by their unique ability of self-renewal to maintain the so-called
stem cell pool. Over the past decades, reactive oxygen species (ROS) have been …

To maintain genome stability, cells have evolved various DNA repair pathways to deal with
oxidative DNA damage. DNA damage response (DDR) pathways, including ATM-Chk2 and …

Radiotherapy is involved in many curative treatments of cancer; millions of survivors live with
the consequences of treatment, and toxicity in a minority limits the radiation doses that can …

The DNA damage response (DDR) rapidly recognizes DNA lesions and initiates the
appropriate cellular programs to maintain genome integrity. This includes the coordination of …

Citrate, a substance being related to de novo fatty acid synthesis and tricarboxylic acid
(TCA) cycle, has a pivotal role in cell survival. However, the molecular mechanisms that …