Liver diseases represent a significant global health challenge, thereby necessitating
extensive research to understand their intricate complexities and to develop effective …

The zebrafish pancreas shares its basic organization and cell types with the mammalian
pancreas. In addition, the developmental pathways that lead to the establishment of the …

Complex cytoplasmic nucleotide-sensing mechanisms can recognize foreign DNA based on
a lack of methylation and initiate an immune response to clear the infection. Zebrafish …

Highlights•Epigenetics has emerged as an area of interest for novel drug
discovery.•Epigenetic drugs can revolutionize the treatment of diabetes and …

DNA methylation is crucial for normal development and cellular differentiation in many large-
genome eukaryotes. The small tropical freshwater fish Danio rerio (zebrafish) has recently …

In the developing pancreas, self-renewal of progenitors and patterning of cell fates are
coordinated to ensure the correct size and cellular makeup of the organ. How this …

Pericentromeric satellite repeats are enriched in 5-methylcytosine (5mC). Loss of 5mC at
these sequences is common in cancer and is a hallmark of Immunodeficiency, Centromere …

The role of epigenetics in development has garnered attention in recent years due to their
ability to modulate the embryonic developmental gene expression in response to the …

The adult liver of most vertebrates is predominantly comprised of hepatocytes. However,
these cells must work in concert with biliary, stellate, vascular, and immune cells to …

DNA methylation is one of the key mechanisms underlying the epigenetic regulation of gene
expression. During DNA replication, the methylation pattern of the parent strand is …