Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple organ
systems with diverse presentation, primarily affecting women of reproductive age. Various …

Regenerative medicine promises to greatly impact on human health by improving repair
outcomes in a range of tissues and injury contexts. Successful therapies will rely on …

The role of epigenetics in development has garnered attention in recent years due to their
ability to modulate the embryonic developmental gene expression in response to the …

Marked epigenetic reprogramming is essential to convert terminally differentiated gametes
to totipotent embryos. It remains puzzling why postfertilization global DNA reprogramming …

Ribosome biogenesis underpins cell growth and division. Disruptions in ribosome
biogenesis and translation initiation are deleterious to development and underlie a spectrum …

To gain insight into liver and pancreas development, we investigated the target of 2F11, a
monoclonal antibody of unknown antigen, widely used in zebrafish studies for labeling …

Insulin-producing β cells within the pancreatic islet of Langerhans are responsible for
maintaining glucose homeostasis; the loss or malfunction of β cells results in diabetes …

UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) recruits DNMT1 to
hemimethylated DNA during replication and is essential for maintaining DNA methylation …

Highlights•Conserved function of zebrafish pancreas and liver enable whole-organism drug-
discovery.•The remarkable regenerative capacity of zebrafish unlocks signals for beta-cell …

Obesity is a public health crisis. New methods for amelioration of its consequences are
required because it is very unlikely that the social and economic factors driving it will be …