UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) recruits DNMT1 to
hemimethylated DNA during replication and is essential for maintaining DNA methylation …

Obesity is a public health crisis. New methods for amelioration of its consequences are
required because it is very unlikely that the social and economic factors driving it will be …

Ribosome biogenesis underpins cell growth and division. Disruptions in ribosome
biogenesis and translation initiation are deleterious to development and underlie a spectrum …

The heat shock cognate 71 kDa protein HSPA8 (also known as HSC70), a constitutively
expressed cognate member of the heat shock protein 70 family, plays an essential role in …

In cases of extensive liver injury, biliary epithelial cells (BECs) dedifferentiate into bipotential
progenitor cells (BPPCs), then redifferentiate into hepatocytes and BECs to accomplish liver …

Diabetes, a metabolic disease with multiple causes characterized by high blood sugar, has
become a public health problem. Hyperglycaemia is caused by deficiencies in insulin …

One important component of the cell–cell communication that occurs during regenerative
patterning is bioelectrical signaling. In particular, the regeneration of the tail in Xenopus …

Activation of transposable elements (TEs) can cause cellular damage. Cytoplasmic nucleic
acid sensing pathways evolved to detect pathogens, but can also serve to cull cells with …

Epigenetics alternation of non-genetic variation and genome-wide association study proven
allelic variants may associate with insulin secretion in type 2 diabetes (T2D) development …

Age-related changes in DNA methylation have been demonstrated in mammals, but it
remains unclear as to the generality of this phenomenon in vertebrates, which is a criterion …