DNA methylation is widespread in most species, from bacteria to mammals, and is crucial for
genomic imprinting, gene expression, and embryogenesis. DNA methylation occurs via two …

DNA methylation has been studied comprehensively and linked to both normal
neurodevelopment and neurological diseases. The recent identification of several new DNA …

Deep neural networks can improve the quality of fluorescence microscopy images. Previous
methods, based on Convolutional Neural Networks (CNNs), require time-consuming training …

Ubiquitin-like, containing PHD and RING finger domains 1 (uhrf1) is regulated at the
transcriptional level during the cell cycle and in developing zebrafish embryos. We identify …

Our previous genome-wide association studies showed that DNA methyltransferase 1
(DNMT1) is associated with increased susceptibility to type 2 diabetes (T2D) in Han Chinese …

The zebrafish differs from mammals in that they have six dnmt3 genes as opposed to the two
that can produce a catalytically active protein in mammals. Zebrafish also do not show …

Intestinal tract development is a coordinated process involving signaling among the
progenitors and developing cells from all three germ layers. Development of endoderm …

The ciliary marginal zone (CMZ) of the zebrafish retina contains a population of actively
proliferating resident stem cells, which generate retinal neurons throughout life. The …

Background Previous studies have reported that ultraviolet B (UVB) inhibits DNA
methyltransferase1 (DNMT1) activity in CD4+ T cells from systemic lupus erythematosus …

The chromatin landscape of a cell is dynamic and can be altered by chromatin regulators
that control nucleosome placement and DNA or histone modifications. Together with …