Cell-substrate interactions play a crucial role in the design of better biomaterials and
integration of implants with the tissues. Adhesion is the binding process of the cells to the …

The current development of nanobiotechnologies requires a better understanding of cell–
surface interactions on the nanometre scale. Recently, advances in nanoscale patterning …

Self-organization of colloidal particles on surfaces to form 2D or 3D nanofabrication
templates has been explored actively in the past decade as an effective bottom-up method …

Substrate topography, independently of substrate chemistry, has been reported to have
significant effects on cell behaviour. Based on the use of fabrication techniques developed …

A current medical challenge is the replacement of tissue which can be thought of in terms of
bone tissue engineering approaches. The key problem in bone tissue engineering lies in …

In bone tissue engineering, it is desirable to use materials to control the differentiation of
mesenchymal stem cell populations in order to gain direct bone apposition to implant …

Cell-substratum and cell-cell interactions play crucial roles in biology. Understanding of
these interactions helps explain cell behavior in vitro and in vivo. Ability to manipulate these …

Cells in their native microenvironment interact with three-dimensional (3D) nanofeatures.
Despite many reports on the effects of substrate nanotopography on cells, the independent …

A significant need exists for orthopedic implants that can intrinsically resist bacterial
colonization. In this study, three biomaterials that are used in spinal implants–titanium (Ti) …

Techniques of bone reconstructive surgery are largely based on conventional, non-cell-
based therapies that rely on the use of durable materials from outside the patient's body. In …