Methods and compositions for nucleic acid analysis

S Saxonov - US Patent 9,347,059, 2016 - Google Patents
Provided herein are methods, compositions, and kits for assays, many of which involve
amplification reactions such as digital PCR or droplet digital PCR. The assays may be used …

Droplet-based assay system

BW Colston, BJ Hindson, KD Ness… - US Patent …, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
42311957&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Microfluidic particle-analysis systems

HP Chou, A Daridon, K Farrell, B Fowler… - US Patent …, 2007 - Google Patents
The invention provides systems, including apparatus, methods, and kits, for the microfluidic
manipulation and/or detection of particles, such as cells and/or beads. The invention …

Emerging trends in microfluidics based devices

S Solanki, CM Pandey, RK Gupta… - Biotechnology …, 2020 - Wiley Online Library
One of the major challenges for scientists and engineers today is to develop technologies for
the improvement of human health in both developed and developing countries. However …

Non-invasive fetal genetic screening by digital analysis

S Quake, HMC Fan - US Patent 7,888,017, 2011 - Google Patents
The present methods are exemplified by a process in which maternal blood containing fetal
DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per …

Droplet generation for droplet-based assays

KD Ness, CF Kelly, DA Masquelier - US Patent 9,500,664, 2016 - Google Patents
A system, including method and apparatus, for generating droplets suitable for droplet-
based assays. The disclosed systems may include either one-piece or multi-piece droplet …

Microfluidic device and methods of using same

M Unger, ID Manger, M Lucero, Y Yi… - US Patent …, 2006 - Google Patents
A variety of elastomeric-based microfluidic devices and methods for using and
manufacturing such devices are provided. Certain of the devices have arrays of reaction …

Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing

YMD Lo, RWK Chiu, KC Chan - US Patent App. 12/178,181, 2009 - Google Patents
Embodiments of this invention provide methods, systems, and apparatus for determining
whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a …

Chemical amplification based on fluid partitioning in an immiscible liquid

BL Anderson, BW Colston, CJ Elkin - US Patent App. 12/118,418, 2010 - Google Patents
(56) References Cited(57) ABSTRACT US PATENT DOCUMENTS A system for nucleic acid
amplification of a sample com 4,801,529 A 1, 1989 Perlman prises partitioning the sample …

Method of mixing fluids by coalescence of multiple emulsions

BJ Hindson, BW Colston Jr, KD Ness… - US Patent …, 2015 - Google Patents
US9194861B2 - Method of mixing fluids by coalescence of multiple emulsions - Google Patents
US9194861B2 - Method of mixing fluids by coalescence of multiple emulsions - Google Patents …