Methods and compositions for nucleic acid analysis
S Saxonov - US Patent 9,347,059, 2016 - Google Patents
Provided herein are methods, compositions, and kits for assays, many of which involve
amplification reactions such as digital PCR or droplet digital PCR. The assays may be used …
amplification reactions such as digital PCR or droplet digital PCR. The assays may be used …
Droplet-based assay system
BW Colston, BJ Hindson, KD Ness… - US Patent …, 2015 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
42311957&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
42311957&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Microfluidic particle-analysis systems
HP Chou, A Daridon, K Farrell, B Fowler… - US Patent …, 2007 - Google Patents
The invention provides systems, including apparatus, methods, and kits, for the microfluidic
manipulation and/or detection of particles, such as cells and/or beads. The invention …
manipulation and/or detection of particles, such as cells and/or beads. The invention …
Emerging trends in microfluidics based devices
One of the major challenges for scientists and engineers today is to develop technologies for
the improvement of human health in both developed and developing countries. However …
the improvement of human health in both developed and developing countries. However …
Non-invasive fetal genetic screening by digital analysis
S Quake, HMC Fan - US Patent 7,888,017, 2011 - Google Patents
The present methods are exemplified by a process in which maternal blood containing fetal
DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per …
DNA is diluted to a nominal value of approximately 0.5 genome equivalent of DNA per …
Droplet generation for droplet-based assays
KD Ness, CF Kelly, DA Masquelier - US Patent 9,500,664, 2016 - Google Patents
A system, including method and apparatus, for generating droplets suitable for droplet-
based assays. The disclosed systems may include either one-piece or multi-piece droplet …
based assays. The disclosed systems may include either one-piece or multi-piece droplet …
Microfluidic device and methods of using same
M Unger, ID Manger, M Lucero, Y Yi… - US Patent …, 2006 - Google Patents
A variety of elastomeric-based microfluidic devices and methods for using and
manufacturing such devices are provided. Certain of the devices have arrays of reaction …
manufacturing such devices are provided. Certain of the devices have arrays of reaction …
Diagnosing fetal chromosomal aneuploidy using massively parallel genomic sequencing
YMD Lo, RWK Chiu, KC Chan - US Patent App. 12/178,181, 2009 - Google Patents
Embodiments of this invention provide methods, systems, and apparatus for determining
whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a …
whether a fetal chromosomal aneuploidy exists from a biological sample obtained from a …
Chemical amplification based on fluid partitioning in an immiscible liquid
BL Anderson, BW Colston, CJ Elkin - US Patent App. 12/118,418, 2010 - Google Patents
(56) References Cited(57) ABSTRACT US PATENT DOCUMENTS A system for nucleic acid
amplification of a sample com 4,801,529 A 1, 1989 Perlman prises partitioning the sample …
amplification of a sample com 4,801,529 A 1, 1989 Perlman prises partitioning the sample …
Method of mixing fluids by coalescence of multiple emulsions
BJ Hindson, BW Colston Jr, KD Ness… - US Patent …, 2015 - Google Patents
US9194861B2 - Method of mixing fluids by coalescence of multiple emulsions - Google Patents
US9194861B2 - Method of mixing fluids by coalescence of multiple emulsions - Google Patents …
US9194861B2 - Method of mixing fluids by coalescence of multiple emulsions - Google Patents …