Significance: Oxidative stress is thought to account for aberrant redox homeostasis and
contribute to aging and disease. However, more often than not, administration of …

The world population continues to grow older rapidly, mostly because of declining fertility
and increasing longevity. Since age represents the largest risk factor for cardiovascular …

Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …

Free radical-induced macromolecular damage has been studied extensively as a
mechanism of oxidative stress, but large-scale intervention trials with free radical …

Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. It can occur at any
age but is very rare in children and becomes extremely common in the elderly, with a …

Methods This was a substudy of a multicenter trial in which nonbleeding critically ill patients
with an increased International Normalized Ratio (1.5 to 3.0) were randomized to omitting or …

Oxidative stress has been suggested to play a role in the pathogenesis of atrial fibrillation
(AF). Indeed, the prevalence of AF increases with age as does oxidative stress. However …

Extracellular thiol/disulfide redox environments are highly regulated in healthy individuals.
The major thiol/disulfide redox couple in human plasma is cysteine (Cys) and its disulfide …

Background—Atrial fibrillation (AF) is a growing public health problem without adequate
therapies. Angiotensin II and reactive oxygen species are validated risk factors for AF in …

The prevalence of obesity and atrial fibrillation (AF), which are inextricably linked, is rapidly
increasing worldwide. Obesity rates are higher among patients with AF than healthy …