SINCE ITS FIRST recognition in 1948, the fifth base of human DNA, 5-methylcytosine (5-mC)
has generated much interest and considerable controversy during attempts to understand its …

Organisms can change their physiological/behavioural traits to adapt and survive in
changed environments. However, whether these acquired traits can be inherited across …

Malignant gliomas are central nervous system tumors and remain among the most treatment-
resistant cancers. Exome sequencing has revealed significant heterogeneity and important …

A small portion of the cytosine residues in the DNA of higher eukaryotes as well as in that of
many lowe eukaryotes if methylated. The resulting 5-methylcytosine residues occur in …

Methionine adenosyltransferase (MAT) is an ubiquitous enzyme that catalyzes the synthesis
of S-adenosylmethionine from methionine and ATP. In mammals, there are two genes …

We have examined the methylation status of two cellular oncogenes, c-Ha-ras and c-Ki-ras,
in primary human carcinomas and the adjacent analogous normal tissues from which the …

Oxidative DNA damage is a major cause of cell death and mutagenesis in all aerobic
organisms, and several new oxidative base lesions have been identified in recent years …

Although epidemiological data provide evidence that early life experience plays a critical
role in human development, the mechanism of how this works remains in question. Recent …

The genome is programmed by the epigenome. Two of the fundamental components of the
epigenome are chromatin structure and covalent modification of the DNA molecule itself by …

The regulation of gene transcription is not simply dependent on the presence or absence of
DNA-binding transcription factors that turn genes on or off, but also involves processes …