Posttransplantation lymphoproliferative disorders (PTLDs) represent a serious complication
of solid organ transplantation. This study assessed the molecular histogenesis of 52 B-cell …

B cells are unique in that they generate and tolerate a high rate of mutations in their antigen
receptor genes and employ these mutations as a basis of avidity maturation. The precise …

The pathogenesis of diffuse large B-cell lymphoma (DLBCL) remains partially unknown. The
analysis of the B-cell receptor of the malignant cells could contribute to a better …

Despite increasing identification of concurrent gastric and intestinal lymphomas of mucosa-
associated lymphoid tissue (MALT), the clonal relationship between the two tumors and their …

Somatic hypermutation (SHM) underlies the generation of a diverse repertoire of high-affinity
antibodies. It is effected by a two-step process:(i) DNA lesions initiated by activation-induced …

There exists a wide spectrum of IgM-secreting B-cell tumors with different clinical behavior.
Knowledge of the VH gene status can reveal their origin and clonal history. For Waldenstrom …

Convergence of observations from different sources is the norm in science. However, when
convergence occurs in man for antibodies it is remarkable because the repertoire of …

BACKGROUND AND OBJECTIVES: To clarify the relationship between splenic (SMZL) and
nodal marginal zone (NMZL) lymphomas, we analyzed immunoglobulin variable heavy …

Sjögren's syndrome (SS) represents a pathological model of the evolution from polyclonal B
lymphocyte activation to oligoclonal/monoclonal B cell expansion, which may culminate in …

Somatic hypermutation (SHM) of the immunoglobulin variable (IgV) loci is a key process in
antibody affinity maturation. The enzyme activation-induced deaminase (AID), initiates SHM …