Ferroptosis induced by pollutants: an emerging mechanism in environmental toxicology

L Yang, X Cai, R Li - Environmental Science & Technology, 2024 - ACS Publications
Environmental pollutants have been recognized for their ability to induce various adverse
outcomes in both the environment and human health, including inflammation, apoptosis …

Effects of ferroptosis on male reproduction

Y Liu, X Cao, C He, X Guo, H Cai, A Aierken… - International journal of …, 2022 - mdpi.com
Ferroptosis is a relatively novel form of regulated cell death that was discovered in 2012.
With the increasing research related to the mechanisms of ferroptosis, previous studies have …

Review of the role of ferroptosis in testicular function

X Yang, Y Chen, W Song, T Huang, Y Wang, Z Chen… - Nutrients, 2022 - mdpi.com
Iron is an important metal element involved in the regulation of male reproductive functions
and has dual effects on testicular tissue. A moderate iron content is necessary to maintain …

Molybdenum and cadmium cause blood–testis barrier dysfunction through ROS-mediated NLRP3 inflammasome activation in sheep

L Jiang, F Yang, H Liao, W Chen, X Dai, C Peng… - Science of the Total …, 2024 - Elsevier
In this study, 24 healthy male sheep were divided into four groups: the control group, Mo
group (45 mg Mo· kg-1· BW), Cd group (1 mg Cd· kg-1· BW), and Mo+ Cd group (45 mg Mo …

Ferroptosis: a novel type of cell death in male reproduction

Y Su, Z Liu, K Xie, Y Ren, C Li, W Chen - Genes, 2022 - mdpi.com
Ferroptosis, an iron-dependent type of regulated cell death, is triggered by the accumulation
of lethal lipid peroxides. Due to its potential in exploring disease progression and highly …

[HTML][HTML] Disease types and pathogenic mechanisms induced by PM2. 5 in five human systems: An analysis using omics and human disease databases

S Zhang, X Li, L Zhang, Z Zhang, X Li, Y Xing… - Environment …, 2024 - Elsevier
Atmospheric fine particulate matter (PM 2.5) can harm various systems in the human body.
Due to limitations in the current understanding of epidemiology and toxicology, the disease …

FTO mediates bisphenol F-induced blood-testis barrier impairment through regulating ferroptosis via YTHDF1/TfRc and YTHDF2/SLC7A11 signal axis

Y Shi, L Yin, J Li, S Zhou, N Wang, H Chen, Y Zeng… - Environmental …, 2024 - Elsevier
Bisphenol F (BPF) has been extensively utilized in daily life, which brings new hazards to
male reproductive health. However, the specific functional mechanism is still unclear. Both …

Melatonin regulates mitochondrial function to alleviate ferroptosis through the MT2/Akt signaling pathway in swine testicular cells

Y Zhao, G Qin, B Jiang, J Huang, S He, H Peng - Scientific Reports, 2024 - nature.com
Increasing evidence has shown that many environmental and toxic factors can cause
testicular damage, leading to testicular ferroptosis and subsequent male reproductive …

[HTML][HTML] Delta-9-tetrahydrocannabinol blocks bone marrow-derived macrophage differentiation through elimination of reactive oxygen species

TH Carter, CE Weyer-Nichols, JI Garcia-Sanchez… - Antioxidants, 2024 - mdpi.com
Macrophages are vital components of the immune system and serve as the first line of
defense against pathogens. Macrophage colony-stimulating factor (M-CSF) induces …

Emerging roles of ferroptosis in male reproductive diseases

W Yuan, Z Sun, G Ji, H Hu - Cell Death Discovery, 2023 - nature.com
Ferroptosis is a type of programmed cell death mediated by iron-dependent lipid
peroxidation that leads to excessive lipid peroxidation in different cells. Ferroptosis is distinct …