This article reviews the regulation of production of RBCs at several levels. We focus on the
regulated expansion of burst-forming unit-erythroid erythroid progenitors by glucocorticoids …

The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway
under both physiological and pathophysiological conditions. Tight regulation of its …

Genes encoding human β-type globin undergo a developmental switch from embryonic to
fetal to adult-type expression. Mutations in the adult form cause inherited …

β-Thalassemia and sickle cell disease (SCD) are the world's two most widely disseminated
hereditary hemoglobinopathies. β-Thalassemia originated in the Mediterranean, Middle …

Erythroid cells and megakaryocytes are derived from a common precursor, the
megakaryocyte-erythroid progenitor. Although these 2 closely related hematopoietic cell …

Disorders in hemoglobin (hemoglobinopathies) were the first monogenic diseases to be
characterized and remain among the most common and best understood genetic conditions …

The major β‐haemoglobinopathies, sickle cell disease and β‐thalassaemia, represent the
most common monogenic disorders worldwide and a steadily increasing global disease …

Reactivating silenced γ-globin expression through the disruption of repressive regulatory
domains offers a therapeutic strategy for treating β-hemoglobinopathies. Here, we used …

Here we report an integrated analysis that leverages data from treatment of genetic mouse
models of prostate cancer along with clinical data from patients to elucidate new …

Known fetal hemoglobin (HbF) silencers have potential on-target liabilities for rational β-
hemoglobinopathy therapeutic inhibition. Here, through transcription factor (TF) CRISPR …