With regard to the varied, nonculinary uses of hot pepper, there is apparently little new under
the sun. For example, Incas burned dried chili peppers to combat the invading Spaniards by …

This review discusses principal patterns that govern the processes of lignins' catalytic
oxidation into vanillin (3-methoxy-4-hydroxybenzaldehyde) and syringaldehyde (3, 5 …

Despite the progress that has occurred in recent years in the development of therapy, there
is still a need for effective and potent analgesics, especially for the treatment of chronic pain …

Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a primary pungent and irritating principle
present in chilies and red peppers which are widely used as spices. Because of its selective …

Capsaicin (CAP), a neurotoxin, has been reported to activate a nonselective cation current
in dorsal root ganglion (DRG) neurons. In this paper, we identify and describe the properties …

Compounds related to capsaicin and its ultrapotent analog, resiniferatoxin (RTX),
collectively referred to as vanilloids, interact at a specific membrane recognition site …

The cloned vanilloid (capsaicin) receptor subtype 1 (VR1) integrates multiple noxious stimuli
on peripheral terminals of primary sensory neurons. The initial excitation of these neurons is …

Capsaicin was postulated to exert its pharmacological actions by interacting at a specific
recognition site (receptor) expressed predominantly by primary afferent neurons. 2. The …

Isosteric replacement of the phenolic hydroxyl group in potent vanilloid receptor (VR1)
agonists with the alkylsulfonamido group provides a series of compounds which are …

The present study examined the antinociceptive effects of agmatine in chemical behavioural
models of pain. Agmatine (1–30 mg/kg), given by ip route, 30 min earlier, produced dose …