Targeting carbonic anhydrase IX and XII isoforms with small molecule inhibitors and monoclonal antibodies
Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …
that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide …
Anticancer carbonic anhydrase inhibitors: a patent and literature update 2018-2022
Introduction Cancer affects an increasing number of patients each year with an
unacceptable death toll worldwide. A new therapeutic approach to combat tumors consists …
unacceptable death toll worldwide. A new therapeutic approach to combat tumors consists …
A review on 'sulfonamides': their chemistry and pharmacological potentials for designing therapeutic drugs in medical science
The discovery of new chemical entities having enhanced bioactivities and improved
functionalities to overcome the prevailing antibiotic resistance and emerging diseases has …
functionalities to overcome the prevailing antibiotic resistance and emerging diseases has …
Atropo/Tropo flexibility: a tool for design and synthesis of self-adaptable inhibitors of carbonic anhydrases and their antiproliferative effect
J Ivanova, A Nocentini, K Tars, J Leita̅ns… - Journal of Medicinal …, 2023 - ACS Publications
Here, we report for the first time a series of sulfonamide derivatives with scaffolds bearing
flexible moieties, namely, rotamers or tropoisomers capable of adapting their geometry in …
flexible moieties, namely, rotamers or tropoisomers capable of adapting their geometry in …
4-(3-Alkyl/benzyl-guanidino) benzenesulfonamides as selective carbonic anhydrase VII inhibitors
The treatment of chronic neuropathic pain remains one of the most challenging of all
neurological diseases and very much an art. There exists no consensus for the optimal …
neurological diseases and very much an art. There exists no consensus for the optimal …
Pyrazolo [4, 3-c] pyridine Sulfonamides as Carbonic Anhydrase Inhibitors: Synthesis, Biological and In Silico Studies
A Angeli, V Kartsev, A Petrou, B Lichitsky… - Pharmaceuticals, 2022 - mdpi.com
Carbonic anhydrases (CAs, EC 4.2. 1.1) catalyze the essential reaction of CO2 hydration in
all living organisms, being actively involved in the regulation of a plethora of patho …
all living organisms, being actively involved in the regulation of a plethora of patho …
Continued structural exploration of sulfocoumarin as selective inhibitor of tumor-associated human carbonic anhydrases ix and XII
A series of new 3-and 7-substituted sulfocoumarins was obtained by several cyclization
reactions and subsequent derivatization for screening as prodrug inhibitors of the human (h) …
reactions and subsequent derivatization for screening as prodrug inhibitors of the human (h) …
Structural Modification Strategies of Triazoles in Anticancer Drug Development
Q Guan, Z Gao, Y Chen, C Guo, Y Chen… - European Journal of …, 2024 - Elsevier
The triazole functional group plays a pivotal role in the composition of biomolecules with
potent anticancer activities, including numerous clinically approved drugs. The strategic …
potent anticancer activities, including numerous clinically approved drugs. The strategic …
6‐Aminocoumarin oxime‐ether/sulfonamides as selective hCA IX and XII inhibitors: Synthesis, evaluation, and molecular dynamics studies
Carbonic anhydrase isoforms IX and XII are overexpressed in hypoxic tumor cells regulating
various physiological processes such as cell proliferation, invasion, and metastasis …
various physiological processes such as cell proliferation, invasion, and metastasis …
Sulfonamides linked to sulfonate esters via hydrazone functionality: synthesis, human carbonic anhydrase inhibitory activities, and molecular modeling studies
In the present study, we synthesized novel carbonic anhydrase (CA, EC 4.2. 1.1) inhibitors
by linking various sulfonate esters to a benzenesulfonamide fragment via hydrazone …
by linking various sulfonate esters to a benzenesulfonamide fragment via hydrazone …