[PDF][PDF] NAT10-mediated ac4C tRNA modification promotes EGFR mRNA translation and gefitinib resistance in cancer
W Wei, S Zhang, H Han, X Wang, S Zheng, Z Wang… - Cell Reports, 2023 - cell.com
Aberrant RNA modifications are frequently associated with cancers, while the underlying
mechanisms and clinical significance remain poorly understood. Here, we find that the ac4C …
mechanisms and clinical significance remain poorly understood. Here, we find that the ac4C …
An outlook of docking analysis and structure-activity relationship of pyrimidine-based analogues as EGFR inhibitors against non-small cell lung cancer (NSCLC)
Almost 80% of lung cancer diagnoses each year correspond to non-small cell lung cancer
(NSCLC). The percentage of NSCLC with EGFR overexpression ranges from 40% to 89 …
(NSCLC). The percentage of NSCLC with EGFR overexpression ranges from 40% to 89 …
In silico screening of a series of 1,6-disubstituted 1H-pyrazolo[3,4-d]pyrimidines as potential selective inhibitors of the Janus kinase 3
Rheumatoid arthritis is a common chronic disabling inflammatory disease that is
characterized by inflammation of the synovial membrane and leads to discomfort. In the …
characterized by inflammation of the synovial membrane and leads to discomfort. In the …
Cancer stem cells as a therapeutic target: current clinical development and future prospective
A Philchenkov, A Dubrovska - Stem Cells, 2024 - academic.oup.com
The key role of cancer stem cells (CSCs) in tumor development and therapy resistance
makes them essential biomarkers and therapeutic targets. Numerous agents targeting …
makes them essential biomarkers and therapeutic targets. Numerous agents targeting …
EMab-300 Detects Mouse Epidermal Growth Factor Receptor-Expressing Cancer Cell Lines in Flow Cytometry
N Goto, H Suzuki, T Tanaka, K Ishikawa, T Ouchida… - Antibodies, 2023 - mdpi.com
Epidermal Growth Factor Receptor (EGFR) overexpression or its mutation mediates the
sustaining proliferative signaling, which is an important hallmark of cancer. Human EGFR …
sustaining proliferative signaling, which is an important hallmark of cancer. Human EGFR …
In-silico identification of small molecule benzofuran-1, 2, 3-triazole hybrids as potential inhibitors targeting EGFR in lung cancer via ligand-based pharmacophore …
Lung cancer is one of the most common and deadly types of cancer worldwide, and the
epidermal growth factor receptor (EGFR) has emerged as a promising therapeutic target for …
epidermal growth factor receptor (EGFR) has emerged as a promising therapeutic target for …
Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFRWT, EGFRT790M, and EGFRL858R)
Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
series of anticancer agents. Thirty-two new compounds were synthesised where x-ray …
Development of new thieno [2, 3-d] pyrimidines as dual EGFR and STAT3 inhibitors endowed with anticancer and pro-apoptotic activities
HA Elsebaie, TF El-Moselhy, EA El-Bastawissy… - Bioorganic …, 2024 - Elsevier
In part due to the resilience of cellular feedback pathways that develop therapeutic
resistance to targeting the EGFR alone, using EGFR inhibitors alone was demonstrated to …
resistance to targeting the EGFR alone, using EGFR inhibitors alone was demonstrated to …
Novel quinazoline-based dual EGFR/c-Met inhibitors overcoming drug resistance for the treatment of NSCLC: Design, synthesis and anti-tumor activity
H Zhang, W Gan, D Fan, P Zheng, Q Lv, Q Pan… - Bioorganic …, 2024 - Elsevier
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have demonstrated
the ability to impede tumor cell proliferation by suppressing EGFR expression. Nonetheless …
the ability to impede tumor cell proliferation by suppressing EGFR expression. Nonetheless …
Synthesis of novel pyrimido[4,5‐b]quinoline derivatives as dual EGFR/HER2 inhibitors as anticancer agents
NSM Ibrahim, HH Kadry, AF Zaher… - Archiv der …, 2024 - Wiley Online Library
A series of novel N‐aryl‐5‐aryl‐6, 7, 8, 9‐tetrahydropyrimido [4, 5‐b] quinolin‐4‐amines 4a–
4l was synthesized as potential anticancer agents through Dimroth rearrangement reaction …
4l was synthesized as potential anticancer agents through Dimroth rearrangement reaction …