Pex14p is a central component of the peroxisomal protein import machinery, which has
been suggested to provide the point of convergence for PTS1-and PTS2-dependent protein …

Several proteins have been identified that catalyze the import of proteins into peroxisomes.
Some recognize specific peroxisomal targeting sequences, but most probably work further …

Human peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous
autosomal-recessive diseases caused by mutations in PEX genes that encode peroxins …

Abstract In trypanosomatids (Trypanosoma and Leishmania), protozoa responsible for
serious diseases of mankind in tropical and subtropical countries, core carbohydrate …

In humans, defects in peroxisome assembly result in the peroxisome biogenesis disorders
(PBDs), a group of genetically heterogeneous, lethal recessive diseases. We have identified …

Peroxisome maintenance depends on the import of nuclear‐encoded proteins from the
cytosol. The vast majority of these proteins is destined for the peroxisomal lumen and …

Protein import into peroxisomes relies on the import receptor Pex5, which recognizes
proteins with a peroxisomal targeting signal 1 (PTS1) in the cytosol and directs them to a …

‡ Academic Medical Centre, Departments of Clinical Chemistry and Paediatrics, University
of Amsterdam, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands† e-mail: kwa …

▪ Abstract The segregation of metabolic functions within discrete organelles is a hallmark of
eukaryotic cells. These compartments allow for the concentration of related metabolic …

We report here that a monomeric de novo designed α-helix-turn-α-helix peptide, αtα, when
incubated at 37 C in an aqueous buffer at neutral pH, forms nonbranching, protease …