Muscarinic acetylcholine receptors (mAChRs), M1–M5, regulate the activity of numerous
fundamental central and peripheral functions. The lack of small-molecule ligands that can …

At the most fundamental level, the bowel facilitates absorption of small molecules, regulates
fluid and electrolyte flux, and eliminates waste. To successfully coordinate this complex …

Parasympathetic signalling via muscarinic acetylcholine receptors (mAChRs) regulates
gastrointestinal smooth muscle function. In most instances, the mAChR population in smooth …

G protein-coupled receptors (GPCRs) comprise the largest and most diverse family of
integral membrane proteins that participate in different physiological processes such as the …

Acetylcholine is a transmitter in preganglionic autonomic and postganglionic
parasympathetic nerves and a non-neuronal paracrine mediator in the alimentary tract …

Acetylcholine acting on muscarinic M3 receptors on the detrusor muscle is the principal
stimulus for inducing the contractile response for urinary bladder voiding. The urinary …

Non‐technical summary Interstitial cells of Cajal (ICC) are tightly associated with excitatory
and inhibitory motor neurons in the gastrointestinal tract, and these cells are also connected …

Systemic sclerosis (SSc) IgGs affecting the M3-muscarinic receptor (M3-R) have been
proposed to be responsible for the gastrointestinal (GI) dysmotility in this disease. However …

Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline were
first described more than three decades ago. Molecular cloning has resulted in the …

Ethnopharmacological relevance Prangos ferulacea (L.) Lindl is an Apiaceae plant, widely
used in traditional medicine. Recently, chemical composition and biological activities of its …