[HTML][HTML] Nanoparticles augment the therapeutic window of RT and immunotherapy for treating cancers: pivotal role of autophagy

YH Wu, RJ Chen, HW Chiu, LX Yang, YL Wang… - Theranostics, 2023 - ncbi.nlm.nih.gov
Immunotherapies are now emerging as an efficient anticancer therapeutic strategy. Cancer
immunotherapy utilizes the host's immune system to fight against cancer cells and has …

[HTML][HTML] Lipophagy: Molecular mechanisms and implications in hepatic lipid metabolism

S Feng, Z Sun, X Jia, L Li, Y Wu, C Wu, L Lin… - Frontiers in Bioscience …, 2023 - imrpress.com
The liver is the most significant metabolic organ in the body and plays an important role in
lipid metabolism. Liver lipid metabolism disorders cause hepatic diseases such as hepatitis …

The pleiotropic AMPK–CncC signaling pathway regulates the trade-off between detoxification and reproduction

H Jiang, X Meng, N Zhang, H Ge… - Proceedings of the …, 2023 - National Acad Sciences
The association of decreased fecundity with insecticide resistance and the negative
sublethal effects of insecticides on insect reproduction indicates the typical trade-off between …

The protective effects of icariin against testicular dysfunction in type 1 diabetic mice Via AMPK-mediated Nrf2 activation and NF-κB p65 inhibition

CS Lu, CY Wu, YH Wang, QQ Hu, RY Sun, MJ Pan… - Phytomedicine, 2024 - Elsevier
Background Owing to the early suffering age and the rising incidence of type 1 diabetes
(T1D), the resulting male reproductive dysfunction and fertility decline have become a …

Therapeutic exploration of polyherbal formulation against letrozole induced PCOS rats: a mechanistic approach

A Balasubramanian, S Pachiappan, S Mohan… - Heliyon, 2023 - cell.com
Objective This study aimed to develop an effective alternative medicine with multi potential
herbs against polycystic ovarian syndrome (PCOS) in rats induced by letrozole treatment …

Effects of Nobiletin supplementation on the freezing diluent on porcine sperm cryo-survival and subsequent in vitro embryo development

A Almubarak, S Lee, IJ Yu, Y Jeon - Theriogenology, 2024 - Elsevier
Nobiletin (NOB) is a bioflavonoid compound isolated from citrus fruit peels. The present
study aimed to elucidate whether NOB facilitates the porcine sperm cryosurvival and embryo …

Oocyte metabolic function, lipid composition, and developmental potential are altered by diet in older mares

GD Catandi, L LiPuma, YM Obeidat… - …, 2022 - rep.bioscientifica.com
Dietary supplementation is the most feasible method to improve oocyte function and
developmental potential in vivo. During three experiments, oocytes were collected from …

Melatonin attenuates di-(2-ethylhexyl) phthalate-induced apoptosis of human granulosa cells by inhibiting mitochondrial fission

R Xue, S Li, Z Wei, Z Zhang, Y Cao - Reproductive Toxicology, 2022 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP) is one of the most used plasticizers which have
contaminated environment widely, and its extensive use causes female reproductive injury …

Maternal and paternal obesity differentially reprogram the ovarian mitochondrial biogenesis of F1 female rats

AG Ramadan, WM Abdel-Rehim, RA El-Tahan… - Scientific Reports, 2023 - nature.com
Obesity has harmful consequences on reproductive outcomes and the rapid increase in
obesity is assumed to be influenced by epigenetics and trans-generation effects. Our study …

Lead intoxication‐induced exosomes promote autophagy and apoptosis in renal proximal tubule cells by activating the adenosine 5'‐monophosphate‐activated …

Q Jiang, X Feng, J Shen, Y Wang… - Environmental …, 2023 - Wiley Online Library
Lead (Pb) intoxication is known to damage the proximal tubules of kidney. Autophagy and
apoptosis have been shown to be involved in a variety of renal injuries, but the underlying …