The clinical success of cancer immune checkpoint blockade (ICB) has refocused attention
on tumor-infiltrating lymphocytes (TILs) across cancer types. The outcome of immune …

CD8 T cells comprising the memory pool display considerable heterogeneity, with individual
cells differing in phenotype and function. This review will focus on our current understanding …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of vaccinated
individuals is increasingly common but rarely results in severe disease, likely due to the …

SARS-CoV-2 mRNA vaccines have shown remarkable clinical efficacy, but questions
remain about the nature and kinetics of T cell priming. We performed longitudinal antigen …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

T cells are the major arm of the immune system responsible for controlling and regressing
cancers. To identify genes limiting T cell function, we conducted genome-wide CRISPR …

From a technical point of view a flow cytometer is a light detection device capable of
detecting photons of different wavelengths over a high dynamic range. In order to achieve a …

Most tissues are populated by tissue-resident memory T cells (TRM cells), which are
adapted to their niche and appear to be indispensable for local protection against …

Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

Infections induce pathogen-specific T cell differentiation into diverse effectors (Teff) that give
rise to memory (Tmem) subsets. The cell-fate decisions and lineage relationships that …