About 10 distinct potassium channels in the heart are involved in shaping the action
potential. Some of the K+ channels are primarily responsible for early repolarization …

G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …

G protein-dependent signaling pathways control the activity of excitable cells of the nervous
system and heart, and are the targets of neurotransmitters, clinically relevant drugs, and …

There are seven sub-families of Kir channels (Table 1), many of which have several
members. The sub-families are denoted Kit1. 0 to Kit7. 0 in the nomenclature introduced by …

A number of different ion channel types are involved in cell signaling networks, and
homeostatic regulatory mechanisms contribute to the control of ion channel expression …

Insulin secretion inhibitors (ISI) such as adrenaline and somatostatin act on the pancreatic β-
cell by a number of mechanisms, one of which is plasma membrane hyperpolarization …

Background Increased nociceptive neuronal excitability underlies chronic pain conditions.
Various ion channels, including sodium, calcium and potassium channels have pivotal roles …

Drugs of abuse can “hijack” synaptic plasticity, a physiological basis of learning and
memory, establishing maladaptations that can promote drug addiction. A wealth of data …

The aim of this study was to investigate the impact of increased mRNA levels encoding
GIRK1 in breast tumours on GIRK protein expression. mRNA levels encoding hGIRK1 and …

G protein-coupled inward rectifier potassium channels (GIRK, Kir3) play a crucial role in
determining neuronal excitability. Currently, four mammalian GIRK members (GIRK1–4) …