Multiple sclerosis genetics—is the glass half full, or half empty?

JR Oksenberg, SE Baranzini - Nature Reviews Neurology, 2010 - nature.com
Multiple sclerosis (MS) is a common and severe CNS disorder that is characterized by
myelin loss, chronic inflammation, axonal and oligodendrocyte pathology, and progressive …

[HTML][HTML] Human endogenous retroviruses and multiple sclerosis: innocent bystanders or disease determinants?

JM Antony, AM DesLauriers, RK Bhat… - … et Biophysica Acta (BBA …, 2011 - Elsevier
Human endogenous retroviruses (HERVs) constitute 5–8% of human genomic DNA and are
replication incompetent despite expression of individual HERV genes from different …

Prevalence of extracranial venous narrowing on catheter venography in people with multiple sclerosis, their siblings, and unrelated healthy controls: a blinded, case …

AL Traboulsee, KB Knox, L Machan, Y Zhao, I Yee… - The Lancet, 2014 - thelancet.com
Background Chronic cerebrospinal venous insufficiency has been proposed as a unique
combination of extracranial venous blockages and haemodynamic flow abnormalities that …

Genetics and familial distribution of multiple sclerosis: A review

A Balcerac, C Louapre - Revue Neurologique, 2022 - Elsevier
Purpose of review This article reviews the genetics of multiple sclerosis (MS), as well as intra-
familial concordance and clinical correlations between different members of a family …

Systematic literature review and meta-analysis of the prevalence of secondary progressive multiple sclerosis in the USA, Europe, Canada, Australia, and Brazil

V Vasanthaprasad, V Khurana, S Vadapalle, J Palace… - BMC neurology, 2022 - Springer
Background Secondary progressive multiple sclerosis (SPMS) is a subtype of multiple
sclerosis (MS), which is a chronic neurological disease, characterised by inflammation of the …

A case of double standard: Sex differences in multiple sclerosis risk factors

B Angeloni, R Bigi, G Bellucci, R Mechelli… - International Journal of …, 2021 - mdpi.com
Multiple sclerosis is a complex, multifactorial, dysimmune disease prevalent in women. Its
etiopathogenesis is extremely intricate, since each risk factor behaves as a variable that is …

[HTML][HTML] Epigenetic mechanisms in multiple sclerosis and the major histocompatibility complex (MHC)

AM Burrell, AE Handel, SV Ramagopalan… - Discovery …, 2011 - discoverymedicine.com
Multiple sclerosis (MS) is a complex disorder of the central nervous system characterized by
demyelination, axonal loss, and inflammation. The cause of MS is currently unknown …

Prevalence of multiple sclerosis in an urban population of Sivas province in Turkey

ŞF Gökçe, B Çiğdem, SN Karaca… - Turkish Journal of …, 2019 - journals.tubitak.gov.tr
Background/aim: Multiple sclerosis (MS) is a common neurological disorder that can be a
leading cause of nontraumatic disability in several countries. Recent reports have indicated …

Anticipation of age at onset in familial multiple sclerosis

L Romero‐Pinel, S Martínez‐Yélamos… - European journal of …, 2010 - Wiley Online Library
Background and objective: Anticipation of age at onset in the younger generations is a
widely known characteristic of many diseases with genetic inheritance. This study was …

Genomic imprinting: a missing piece of the multiple sclerosis puzzle?

S Ruhrmann, P Stridh, L Kular, M Jagodic - The international journal of …, 2015 - Elsevier
Evidence for parent-of-origin effects in complex diseases such as Multiple Sclerosis (MS)
strongly suggests a role for epigenetic mechanisms in their pathogenesis. In this review, we …