Abstract Ferroptosis suppressor protein 1 (FSP1) is one of the main regulatory molecules of
ferroptosis. FSP1 functions through the FSP1-coenzyme Q10 (CoQ10)-NAD (P) H axis and …

Ferroptosis, a unique modality of cell death with mechanistic and morphological differences
from other cell death modes, plays a pivotal role in regulating tumorigenesis and offers a …

Ferroptosis, marked by iron-dependent lipid peroxidation, may present an Achilles heel for
the treatment of cancers. Ferroptosis suppressor protein-1 (FSP1), as the second ferroptosis …

Ferroptosis and iron-related redox imbalance aggravate traumatic brain injury (TBI)
outcomes. NRF2 is the predominant transcription factor regulating oxidative stress and …

Ferroptosis is inhibited by glutathione peroxidase 4 (GPX4), an antioxidant enzyme that
uses reduced glutathione (GSH) as a cofactor to detoxify lipid hydroperoxides. As a …

The tripeptide glutathione (GSH), namely γ-L-glutamyl-L-cysteinyl-glycine, is an ubiquitous
low-molecular weight thiol nucleophile and reductant of utmost importance, representing the …

Ferroptosis is a mode of cell death regulated by iron-dependent lipid peroxidation. Growing
evidence suggests ferroptosis induction as a novel anti-cancer modality that could …

Ferroptosis has emerged as a therapeutic tactic to trigger cancer cell death driven by
abnormal accumulation of reactive oxygen species (ROS). However, a single ferroptosis …

Ferroptosis is a form of programmed cell death characterized by elevated intracellular
ferrous ion levels and increased lipid peroxidation. Since its discovery and characterization …

Ferroptosis is a newly recognized form of oxidative-regulated cell death resulting from iron-
mediated lipid peroxidation accumulation. Radical-trapping antioxidant systems can …