Over a century ago, Theodor Boveri paved the way to mechanistic studies linking
chromosomal abnormalities to cancer pathogenesis. Since then, theoretical and empirical …

Since the early 1980s, there has been growing concern about potential health
consequences of exposure to second-hand smoke (SHS). Despite SHS being established …

In this case-control study, we modified the cytokinesis-block micronucleus (CBMN) assay, an
established biomarker for genomic instability, to evaluate susceptibility to the nicotine …

Diets rich in polyphenols are known to reduce cancer among high-risk populations. Haskap
(Lonicera caerulea L.) berry has abundant phenolic acids and flavonoids, especially …

Nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is formed by nitrosation
of nicotine and has been identified as the most potent carcinogen contained in cigarette …

Cancer is one of the leading causes of death worldwide. Chemotherapy and radiation
therapy are currently providing the basis for cancer therapies, although both are associated …

Background Tobacco is considered the most important cause of lung cancer, but other
factors could also be involved in its pathogenesis. The aim of the present work was to …

Cytochromes P450 (CYP) from the 2A subfamily are known for their roles in the metabolism
of nicotine, the addictive agent in tobacco, and activation of the tobacco procarcinogen 4 …

Tobacco-specific N-nitrosamines (TSNAs) are strong carcinogens widely found in tobacco
products, environmental tobacco smoke, lake, and wastewater. The main objective of this …

The multi-endpoint cytokinesis-blocked micronucleus assay is used for assessing
chromosome aberrations. We have recently reported that this assay is extremely sensitive to …