Obesity-driven chronic inflammation and impaired fibrinolysis appear to be major effector
mechanisms of thrombosis in obesity. The proinflammatory and hypofibrinolytic effects of …

Apelin is a peptide known as the ligand of the G-protein-coupled receptor APJ. Several
active apelin forms exist such as apelin-36, apelin-17, apelin-13, and the pyroglutamated …

Introduction Embryogenesis is thought to be directed by a small number of signaling
pathways with most if not all embryonic signals having been identified. However, the …

Background: It has been suggested that the metabolic benefits of physical exercise could be
mediated by myokines. We examined here the effect of exercise training on skeletal muscle …

The effects of brain AngII (angiotensin II) depend on AT1 receptor (AngII type 1 receptor)
stimulation and include regulation of cerebrovascular flow, autonomic and hormonal …

Poor adaptation to stress, alterations in cerebrovascular function and excessive brain
inflammation play critical roles in the pathophysiology of many psychiatric and neurological …

Insulin resistance is a main feature of obesity and type 2 diabetes mellitus (T2DM). Several
mechanisms linking obesity to insulin resistance have been proposed. Adipose tissue …

Apelin is emerging as an important hormone regulator of cardiovascular homoeostasis and
an important biomarker for heart failure. Apelin concentrations have historically been …

Obesity is a risk factor for cardiovascular disease (CVD). However, clinical research has
revealed a paradoxically protective role for obesity in patients with chronic diseases …

Apelin is an adipokine that has been identified as an endogenous ligand for the orphan
receptor APJ. Apelin and APJ are expressed in a diverse range of tissues with particular …