Boosting extracellular vesicle secretion

L Debbi, S Guo, D Safina, S Levenberg - Biotechnology advances, 2022 - Elsevier
In recent years, extracellular vesicles (EVs), specifically exosomes, have emerged as a
promising strategy for treating a wide spectrum of pathologies, such as cancer and COVID …

Engineering extracellular vesicles as delivery systems in therapeutic applications

L Wang, D Wang, Z Ye, J Xu - Advanced Science, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are transport vesicles secreted by living cells and released into
the extracellular environment. Recent studies have shown that EVs serve as “messengers” …

Scalable production of extracellular vesicles and its therapeutic values: a review

CY Ng, LT Kee, ME Al-Masawa, QH Lee… - International Journal of …, 2022 - mdpi.com
Extracellular vesicles (EVs) are minute vesicles with lipid bilayer membranes. EVs are
secreted by cells for intercellular communication. Recently, EVs have received much …

Methods of the large-scale production of extracellular vesicles

V Syromiatnikova, A Prokopeva… - International Journal of …, 2022 - mdpi.com
To date, extracellular vesicles (EVs) have been extensively investigated as potential
substitutes for cell therapy. Research has suggested their ability to overcome serious risks …

[HTML][HTML] Small extracellular vesicles derived from hypoxic mesenchymal stem cells promote vascularized bone regeneration through the miR-210-3p/EFNA3/PI3K …

Y Zhuang, M Cheng, M Li, J Cui, J Huang, C Zhang… - Acta biomaterialia, 2022 - Elsevier
Angiogenesis is closely coupled with osteogenesis and has equal importance. Thus,
promoting angiogenesis during the bone repair process is vital for ideal bone regeneration …

[HTML][HTML] Extracellular vesicles as bioactive nanotherapeutics: an emerging paradigm for regenerative medicine

M Li, F Fang, M Sun, Y Zhang, M Hu, J Zhang - Theranostics, 2022 - ncbi.nlm.nih.gov
In recent decades, extracellular vesicles (EVs), as bioactive cell-secreted nanoparticles
which are involved in various physiological and pathological processes including cell …

Biogenesis, composition and potential therapeutic applications of mesenchymal stem cells derived exosomes in various diseases

YG Yuan, JL Wang, YX Zhang, L Li… - International Journal …, 2023 - Taylor & Francis
Exosomes are nanovesicles with a wide range of chemical compositions used in many
different applications. Mesenchymal stem cell-derived exosomes (MSCs-EXOs) are …

Mechanoelectronic stimulation of autologous extracellular vesicle biosynthesis implant for gut microbiota modulation

S Wan, K Wang, P Huang, X Guo, W Liu, Y Li… - Nature …, 2024 - nature.com
Pathogenic gut microbiota is responsible for a few debilitating gastrointestinal diseases.
While the host immune cells do produce extracellular vesicles to counteract some …

Spinal cord repair: from cells and tissue engineering to extracellular vesicles

S Guo, I Redenski, S Levenberg - Cells, 2021 - mdpi.com
Spinal cord injury (SCI) is a debilitating condition, often leading to severe motor, sensory, or
autonomic nervous dysfunction. As the holy grail of regenerative medicine, promoting spinal …

A Novel Superparamagnetic Multifunctional Nerve Scaffold: A Remote Actuation Strategy to Boost In Situ Extracellular Vesicles Production for Enhanced Peripheral …

B Xia, X Gao, J Qian, S Li, B Yu, Y Hao… - Advanced …, 2024 - Wiley Online Library
Extracellular vesicles (EVs) have inherent advantages over cell‐based therapies in
regenerative medicine because of their cargos of abundant bioactive cues. Several …