The adverse sequalae of inadequate pain control in the burn population have been long
recognised, yet control of pain remains inadequate globally. The dynamic evolution of burn …

Long-term potentiation (LTP) in nociceptive spinal pathways shares several features with
hyperalgesia and has been proposed to be a cellular mechanism of pain amplification in …

BACKGROUND: Ketamine has been shown to have a morphine-sparing effect soon after
surgery. Nevertheless, whether this effect still exists after being combined with nonsteroidal …

Different mechanisms were proposed for opioid-induced analgesia and antihyperalgesia,
which might result in different pharmacodynamics. To address this issue, the time course of …

The antinociception induced by the intraperitoneal coadministration of combinations of
paracetamol with the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, ibuprofen …

What is known and background: Although paracetamol (acetaminophen), N‐(4‐
Hydroxyphenyl) acetamide, is one of the world's most widely used analgesics, the …

Chronic post-surgical pain (CPSP) is a serious complication of major surgery that can impair
a patient's quality of life. The development of CPSP is a complex process which involves …

Despite many advances in the provision of pain services, acute pain after surgery remains a
serious cause of severe suffering that is often undermanaged despite our best efforts. 6 34 …

Non-opioids play an ever increasing role in the treatment of postoperative pain; either on
their own for mild to moderate pain or in combination with other analgesic approaches, in …

Background Numerous experimental and clinical studies suggest that brief opioid exposure
can enhance pain sensitivity. It is suggested that spinal cyclooxygenase activity may …