Club cells are found in human small airways where they play an important role in immune
defense, xenobiotic metabolism, and repair after injury. Over the past few years, data from …

Chronic obstructive pulmonary disease (COPD) is one of the most prevalent chronic adult
diseases, with significant worldwide morbidity and mortality. Although long-term tobacco …

Rationale: Small airway disease is an important pathophysiological feature of chronic
obstructive pulmonary disease (COPD). Recently,“pre-COPD” has been put forward as a …

Patients diagnosed with environmental/occupational bronchiolitis obliterans (BO) over the
last 2 decades often present with an indolent evolution of respiratory symptoms without a …

Rationale: Constrictive bronchiolitis (ConB) is a relatively rare and understudied form of lung
disease whose underlying immunopathology remains incompletely defined. Objectives: Our …

Abstract The role of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) in alveolar
macrophages (AMs) polarization homeostasis is closely associated with airway remodeling …

Objectives Parametric response mapping (PRM) enables the evaluation of small airway
disease (SAD) at the voxel level, but requires both inspiratory and expiratory chest CT …

Rationale: Multiciliated cell (MCC) loss and/or dysfunction is common in the small airways of
patients with chronic obstructive pulmonary disease (COPD), but it is unclear if this …

Abstract Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder, characterized by
panacinar emphysema mainly in the lower lobes, and predisposes to chronic obstructive …

Background Kaempferol has important medicinal value in the treatment of asthma. However,
its mechanism of action has not been fully understood and needs to be explored and …