The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

As a preformed defense system, complement faces a delicate challenge in providing an
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …

The increasing number of clinical conditions that involve a pathological contribution from the
complement system—many of which affect the kidneys—has spurred a regained interest in …

In tumour immunology, complement has traditionally been considered as an adjunctive
component that enhances the cytolytic effects of antibody-based immunotherapies, such as …

Complement is viewed as a critical serum-operative component of innate immunity, with
processing of its key component, C3, into activation fragments C3a and C3b confined to the …

The treatment of paroxysmal nocturnal hemoglobinuria has been revolutionized by the
introduction of the anti-C5 agent eculizumab; however, eculizumab is not the cure for …

Although acute or chronic inflammation is a common component of many clinical disorders,
the underlying processes can be highly distinct. In recent years, the complement system has …

The complement system plays a major role in the autoimmune disease, systemic lupus
erythematosus (SLE). However, the role of complement in SLE is complex since it may both …

The complement system comprises several fluid-phase and membrane-associated proteins.
Under physiological conditions, activation of the fluid-phase components of complement is …

Complement is the major humoral component of the innate immune system. It recognizes
pathogen-and damage-associated molecular patterns, and initiates the immune response in …