Leptomeningeal metastasis (LM), also known as leptomeningeal carcinomatosis (LC), is a
devastating complication of metastatic cancer that occurs when neoplastic cells invade the …

The diagnosis of brain metastasis (BrM) has historically been a dooming diagnosis that is
nothing less than a death sentence, with few treatment options for palliation or prolonging …

PURPOSE In this phase I study (BLOOM), osimertinib, a third-generation epidermal growth
factor receptor (EGFR) tyrosine kinase inhibitor (TKI), was evaluated in patients with …

Background Platinum‐based chemotherapy is effective in inducing shrinkage of primary
lung cancer lesions; however, it shows finite therapeutic efficacy in patients suffering from …

Brain metastasis (BM) is a leading cause of mortality in patients with non-small cell lung
cancer (NSCLC). However, the molecular mechanisms underlying BM of NSCLC remain …

Lung cancer is the most malignant human cancer worldwide, also with the highest incidence
rate. However, small-cell lung cancer (SCLC) accounts for 14% of all lung cancer cases …

Simple Summary During the development and progression of lung tumors, processes such
as necrosis and vascular invasion shed tumor cells or cellular components into various fluid …

Introduction Patients with NSCLC with leptomeningeal metastases (LM) presented dismal
prognosis. Cerebrospinal fluid (CSF) is suggested as a medium of liquid biopsy of LM …

Purpose: Central nervous system metastases are a prominent cause of morbidity and
mortality in patients with ALK-positive (ALK+) non–small cell lung cancer (NSCLC). The …

Liquid biopsies have emerged as a promising tool for the detection of metastases as well as
local and regional recurrence in lung cancer. Liquid biopsy tests involve analyzing a …