Numerous cancer-associated deaths are owing to a lack of effective diagnostic and
therapeutic approaches. Microfluidic systems for analyzing a low volume of samples offer a …

The development of blood vessels, referred to as angiogenesis, is an intricate process
regulated spatially and temporally through a delicate balance between the qualitative and …

The desmoplastic nature of the pancreatic ductal adenocarcinoma (PDAC) tumor
microenvironment (TME) prevents the infiltration of T cells and the penetration of …

Simple Summary Organ-on-a-chip models, or organ chips, are tiny devices designed to
accurately recreate the natural physiology and mechanical forces that cells experience in …

Three-dimensional image analyses are required to improve the understanding of the
regulation of blood vessel formation and heterogeneity. Currently, quantitation of 3D …

The benzothiazole nucleus is a major heterocyclic scaffold whose therapeutic potential has
been thoroughly explored due to its structural simplicity and ease of synthesis. In fact …

Summary Microphysiological systems (MPSs)(ie, tissue or organ chips) exploit microfluidics
and 3D cell culture to mimic tissue and organ-level physiology. The advent of human …

Introduction In order to develop novel anticancer HDAC/tubulin dual inhibitors, a novel
series of α-phthalimido-substituted chalcones-based hybrids was synthesized and …

Nanoparticles (NPs) have found a wide range of applications in clinical therapeutic and
diagnostic fields. However, currently most NPs are still in the preclinical evaluation phase …

Simple Summary Discovering new strategies for cancer treatment is critical, considering that
each year millions of deaths are caused by this disease. In this sense, therapies based on …