Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment

SH Safe - Critical reviews in toxicology, 1994 - Taylor & Francis
Commercial polychlorinated biphenyls (PCBs) and environmental extracts contain complex
mixtures of congeners that can be unequivocally identified and quantitated. Some PCB …

Free radicals, antioxidant enzymes, and carcinogenesis

Y Sun - Free Radical Biology and Medicine, 1990 - Elsevier
Free radicals are found to be involved in both initiation and promotion of multistage
carcinogenesis. These highly reactive compounds can act as initiators and/or promoters …

[图书][B] Handbook of pesticide toxicology: principles and agents

R Krieger - 2001 - books.google.com
This revision of the highly acclaimed Hayes' Handbook of Pesticide Toxicology is an in-
depth, scientific sourcebook concerning use, properties, effects, and regulation of pesticides …

Hepatocarcinogenic potential of di (2-ethylhexyl) phthalate in rodents and its implications on human risk

WW Huber, B Grasl-Kraupp… - Critical reviews in …, 1996 - Taylor & Francis
Abstract The plasticizer di (2-ethylhexyl) phthalate (DEHP), to which humans are extensively
exposed, was found to be hepatocarcinogenic in rats and mice. DEHP is potentially set free …

Inhibition of DNA synthesis in primary rat hepatocyte cultures by malachite green: a new liver tumor promoter

KVK Rao - Toxicology letters, 1995 - Elsevier
Malachite green (MG), a triarylmethane dye is highly cytotoxic to mammalian cells and also
acts as a liver tumourenhancing agent. In view of its industrial importance and possible …

Cell death by apoptosis and its protective role against disease

W Bursch, F Oberhammer… - Trends in pharmacological …, 1992 - cell.com
The involvement of cell death in control of tissue growth has long been neglected, but the
description of apoptosis as cellular 'suicide', the functional opposite of mitosis, is now …

Cellular origin of cancer: dedifferentiation or stem cell maturation arrest?

S Sell - Environmental health perspectives, 1993 - ehp.niehs.nih.gov
Given the fundamental principle that cancer must arise from a cell that has the potential to
divide, two major nonexclusive hypotheses of the cellular origin of cancer are that …

DNA synthesis, apoptosis, and phenotypic expression as determinants of growth of altered foci in rat liver during phenobarbital promotion

R Schulte-Hermann, I Timmermann-Trosiener… - Cancer research, 1990 - AACR
Carcinogenesis was initiated in female rat liver by a single dose of N-nitrosomorpholine;
subsequently phenobarbital (PB) was administered via the diet at a daily dose of 50 mg/kg …

Polychlorinated biphenyls (PCBs): mutagenicity and carcinogenicity

S Safe - Mutation Research/Reviews in Genetic Toxicology, 1989 - Elsevier
Commercial polychlorinated biphenyls (PCBs)(Fig. 1) were widely used as industrial
compounds with such diverse applications as plasticizers, heat transfer fluids, organic …

Antioxidant enzyme activities in normal and transformed mouse liver cells

Y Sun, LW Oberley, JH Elwell… - International Journal of …, 1989 - Wiley Online Library
Copper‐and zinc‐containing superoxide dismutase (Cu‐ZnSOD), manganese‐containing
superoxide dismutase (MnSOD), catalase (CAT), glutathione peroxidase (GPX, both Se …