Studies of complement genetics have changed the landscape of thrombotic
microangiopathies (TMAs), particularly atypical haemolytic uraemic syndrome (aHUS) …

Thrombotic microangiopathy (TMA), a pathological lesion observed in a wide spectrum of
diseases, is triggered by endothelial injury and/or dysfunction. Although TMA lesions are …

Thrombotic microangiopathy (TMA) is a condition characterized by thrombocytopenia and
microangiopathic hemolytic anemia (MAHA) with varying degrees of organ damage in the …

Haemolytic uraemic syndrome (HUS) is a heterogeneous group of diseases that result in a
common pathology, thrombotic microangiopathy, which is classically characterised by the …

The membrane attack complex—also known as C5b-9—is the end-product of the classical,
lectin, and alternative complement pathways. It is thought to play an important role in the …

Overactivation of the complement alternative pathway drives the pathogenesis of primary
atypical hemolytic uremic syndrome (aHUS). Genetically‐determined or acquired …

Malignant hypertension is a hypertensive emergency, with rapid disease progression and
poor prognosis. Although recognized as a separate entity more than a century ago …

Thrombotic microangiopathies (TMA) constitute a group of different disorders that have a
common underlying mechanisim: the endothelial damage. These disorders may exhibit …

Increasing evidence indicates that hypertension and hypertensive end organ damage are
not only mediated by haemodynamic injury but that inflammation also plays an important …

Background The identification of complement defects as major drivers of primary atypical
hemolytic uremic syndrome (HUS) has transformed the landscape of thrombotic …