The field of adenovirology is undergoing rapid change in response to increasing
appreciation of the potential advantages of adenoviruses as the basis for new vaccines and …

Dendritic cells (DCs) are recognized as highly potent antigen-presenting cells that are able
to stimulate cytotoxic T lymphocyte (CTL) responses with antitumor activity. Consequently …

The immunoproteasome (IP) is usually viewed as favoring the production of antigenic
peptides presented by MHC class I molecules, mainly because of its higher cleavage activity …

ABSTRACT A novel plasmid-based adenovirus vector system that enables manufacturing of
replication-incompetent (ΔE1) adenovirus type 11 (Ad11)-based vectors is described. Ad11 …

Dendritic cell (DC) therapies are currently being evaluated for the treatment of cancer. The
majority of ongoing clinical trials use DCs loaded with defined antigenic peptides or …

Microparticulate delivery systems are a promising and versatile enhancement to DNA
vaccines because they can target large payloads of plasmid and immunomodulating …

The outcome of therapy with chimeric Ag receptor (CAR)-modified T cells is strongly
influenced by the subset origin of the infused T cells. However, because polyclonally …

Purpose: Previous studies have indicated that carcinoembryonic antigen (CEA) might be a
suitable immunotherapeutic target in colorectal carcinoma (CRC). The aim of the present …

The primary goal of this study was to evaluate the efficacy of immunotherapy for patients with
metastatic melanoma with autologous melanoma apoptotic bodies (MAB)-pulsed dendritic …

Bacterial ghosts (BG) are cell envelopes preparations of Gram-negative bacteria devoid of
cytoplasmic content produced by controlled expression of PhiX174 plasmid-encoded lysis …