Despite decades of surveillance and pharmaceutical and non-pharmaceutical interventions,
seasonal influenza viruses continue to cause epidemics around the world each year. The …

Objectives Summary evidence of influenza vaccine effectiveness (IVE) against hospitalized
influenza is lacking. We conducted a meta-analysis of studies reporting IVE against …

Vaccination to prevent influenza virus infection and to lessen its severity is recommended
among healthcare workers (HCWs). Health professionals have a higher risk of exposure to …

The imperfect effectiveness of seasonal influenza vaccines is often blamed on antigenic
mismatch, but even when the match appears good, effectiveness can be surprisingly low …

Background Influenza vaccines require annual readministration; however, several reports
have suggested that repeated vaccination might attenuate the vaccine's effectiveness. We …

The term “original antigenic sin”(OAS) was first used in the 1960s to describe how one's first
exposure to influenza virus shapes the outcome of subsequent exposures to antigenically …

Background: The test-negative design is an increasingly popular approach for estimating
vaccine effectiveness (VE) due to its efficiency. This review aims to examine published test …

Background To date, no study has examined influenza vaccine effectiveness (IVE) against
laboratory-confirmed influenza-associated hospitalizations during pregnancy. Methods The …

Background Little is known about inactivated influenza vaccine effectiveness (IVE) in
preventing very severe disease, including influenza-associated intensive care unit (ICU) …

The influenza virus-host interaction is a classic arms race. The recurrent and evolving nature
of the influenza virus family allows a single host to be infected several times. Locked in co …