Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

Non-homologous DNA end joining (NHEJ) is the predominant repair mechanism of any type
of DNA double-strand break (DSB) during most of the cell cycle and is essential for the …

The individual response to ionizing radiation (IR) raises a number of medical, scientific, and
societal issues. While the term “radiosensitivity” was used by the pioneers at the beginning …

Multiple DNA repair pathways maintain genome stability and ensure that DNA remains
essentially unchanged over the life of a cell. Various human diseases occur if DNA repair is …

DNA damage response is essential to human physiology. A broad spectrum of pathologies
are displayed by individuals carrying monoallelic or biallelic loss-of-function mutations in …

While it is well appreciated that loss of the p53 tumor suppressor protein promotes cancer,
growing evidence indicates that increased p53 activity underlies the developmental defects …

NAD+ is a versatile biomolecule acting as a master regulator and substrate in various
cellular processes, including redox regulation, metabolism, and various signaling pathways …

Craniofacial malformations are among the most common birth defects in humans and they
often have significant detrimental functional, aesthetic, and social consequences. To date …

The joining of breaks in the DNA phosphodiester backbone is essential for genome integrity.
Breaks are generated during normal processes such as DNA replication, cytosine …

DNA ligase IV (LigIV) performs the final DNA nick-sealing step of classical nonhomologous
end-joining, which is critical for immunoglobulin gene maturation and efficient repair of …