Although the first ancient DNA molecules were extracted more than three decades ago, the
first ancient nuclear genomes could only be characterized after high-throughput sequencing …

Recent scientific discoveries that resulted from the application of next-generation DNA
sequencing technologies highlight the striking impact of these massively parallel platforms …

Although a rich record of Pleistocene human-associated archaeological assemblages
exists, the scarcity of hominin fossils often impedes the understanding of which hominins …

Claims of extreme survival of DNA have emphasized the need for reliable models of DNA
degradation through time. By analysing mitochondrial DNA (mtDNA) from 158 radiocarbon …

The seminal importance of DNA sequencing to the life sciences, biotechnology and
medicine has driven the search for more scalable and lower-cost solutions. Here we …

John Dupré explores recent revolutionary developments in biology and considers their
relevance for our understanding of human nature and human society. Epigenetics and …

DNA that survives in museum specimens, bones and other tissues recovered by
archaeologists is invariably fragmented and chemically modified. The extent to which such …

Exhaustive gene identification is a fundamental goal in all metagenomics projects. However,
most metagenomic sequences are unassembled anonymous fragments, and conventional …

High-throughput direct sequencing techniques have recently opened the possibility to
sequence genomes from Pleistocene organisms. Here we analyze DNA sequences …

In Europe, the Neolithic transition (8,000–4,000 bc) from hunting and gathering to
agricultural communities was one of the most important demographic events since the initial …