In an increasing number of states and countries, cannabis now stands poised to join alcohol
and tobacco as a legal drug. Quantifying the relative adverse and beneficial effects of …

Cannabinoid hyperemesis syndrome (CHS) is a syndrome of cyclic vomiting associated with
cannabis use. Our objective is to summarize the available evidence on CHS diagnosis …

Cannabis has been used for centuries to treat seizures. Recent anecdotal reports,
accumulating animal model data, and mechanistic insights have raised interest in cannabis …

Cannabis sativa is the source of a unique set of compounds known collectively as plant
cannabinoids or phytocannabinoids. This review focuses on the manner with which three of …

Chronic cannabis (marijuana, hashish) smoking can result in dependence. Rodent studies
show reversible downregulation of brain cannabinoid CB 1 (cannabinoid receptor type 1) …

Research into the pharmacology of individual cannabinoids that began in the 1940s, several
decades after the presence of a cannabinoid was first detected in cannabis, is concisely …

Questions surrounding the effects of chronic marijuana use on brain structure continue to
increase. To date, however, findings remain inconclusive. In this comprehensive study that …

Background Cannabis is one of the most widely used drugs worldwide. Cannabis use
disorder is characterised by recurrent use of cannabis that causes significant clinical and …

Mammalian tissues express at least two cannabinoid receptor types, CB 1 and CB 2, both G
protein coupled. CB 1 receptors are found predominantly at nerve terminals where they …

Objective To promote wider recognition and further understanding of cannabinoid
hyperemesis (CH). Patients and Methods We constructed a case series, the largest to date …