The rise of multi-drug resistant (MDR) pathogens poses a significant challenge to the field of
infectious disease treatment. To overcome this problem, novel strategies are being explored …

Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …

Staphylococcus aureus is a common human pathogen with a variety of virulence factors,
which can cause multiple infectious diseases. In recent decades, due to the constant …

Introduction Understanding the role of efflux pumps in biofilm resistance provides valuable
insights for developing effective therapeutic strategies. Drugs designed for targeting efflux …

Macrolides are empirically used to treat bacterial community-acquired pneumonia (CAP).
Streptococcus pneumoniae, being the major pathogen responsible for bacterial CAP with …

Combining pentamidine with Gram-positive-targeting antibiotics has been proven to be a
promising strategy for treating infections from Gram-negative bacteria (GNB). However …

Antibiotic resistance is a major health problem worldwide. Pseudomonas aeruginosa is a
Gram-negative pathogen with an arsenal of virulence factors and elevated antimicrobial …

Drug repurposing (repositioning) is a dynamically-developing area in the search for effective
therapy of infectious diseases. Repositioning existing drugs with a well-known …

Bacteria express a plethora of efflux pumps that can transport structurally varied molecules,
including antimicrobial agents and antibiotics, out of cells. Thus, efflux pump systems …

The efflux pump mechanism contributes to the antibiotic resistance of widely distributed
strains of Staphylococcus aureus. Therefore, in the present work, the ability of the riparins N …