RNA modification m6Am: the role in cardiac biology

D Benak, F Kolar, L Zhang, Y Devaux, M Hlavackova - Epigenetics, 2023 - Taylor & Francis
Epitranscriptomic modifications have recently emerged into the spotlight of researchers due
to their vast regulatory effects on gene expression and thereby cellular physiology and …

Epigenetic regulation of programmed cell death in hypoxia-induced pulmonary arterial hypertension

Y Jiang, S Song, J Liu, L Zhang, X Guo, J Lu… - Frontiers in …, 2023 - frontiersin.org
Pulmonary arterial hypertension (PAH) is a severe progressive disease that may cause early
right ventricular failure and eventual cardiac failure. The pathogenesis of PAH involves …

[HTML][HTML] Epigenetic mechanisms in vascular inflammation: modulation of endothelial adhesion molecules and endothelium-leukocyte adhesion

N Calabriso, M Massaro, E Scoditti… - Frontiers in Bioscience …, 2023 - imrpress.com
The endothelium, an essential component of the vascular system, plays a critical role in the
inflammatory response. Under pro-inflammatory stimuli, endothelial cells undergo activation …

Effects of moderate-intensity continuous training and high-intensity interval training on testicular oxidative stress, apoptosis and m6A Methylation in obese male mice

Z Xu, Y Qin, B Lv, Z Tian, B Zhang - Antioxidants, 2022 - mdpi.com
Exercise is an effective way to improve reproductive function in obese males. Oxidative
stress and apoptosis are important pathological factors of obesity-related male infertility …

RNA m6A methylation and regulatory proteins in pulmonary arterial hypertension

Z Wang, YX Zhang, JZ Shi, Y Yan, LL Zhao… - Hypertension …, 2024 - nature.com
Abstract m6A (N6‑methyladenosine) is the most common and abundant apparent
modification in mRNA of eukaryotes. The modification of m6A is regulated dynamically and …

[HTML][HTML] N6-methyladenosine RNA methylation in diabetic kidney disease

J Huang, F Yang, Y Liu, Y Wang - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Diabetic kidney disease (DKD) is a major microvascular complication of diabetes, and
hyperglycemic memory associated with diabetes carries the risk of disease occurrence …

RNA methylations in depression, from pathological mechanism to therapeutic potential

C Li, P Xu, Y Huang, Y Wang, Y Wu, H Li… - Biochemical …, 2023 - Elsevier
Depression is caused by a variety of factors such as genetic factors, biological factors, and
psychosocial factors, and the pathogenesis is complex. RNA methylations and related …

[HTML][HTML] N6-methyladenosine in vascular aging and related diseases: clinical perspectives

C Li, L Liu, S Li, YS Liu - Aging and Disease, 2024 - ncbi.nlm.nih.gov
Aging leads to progressive deterioration of the structure and function of arteries, which
eventually contributes to the development of vascular aging-related diseases. N 6 …

Mechanistic exploration on neurodevelopmental toxicity induced by upregulation of alkbh5 targeted by triclosan exposure to larval zebrafish

W Wang, X Li, Q Qian, J Yan, H Huang, X Wang… - Journal of Hazardous …, 2023 - Elsevier
Because triclosan (TCS) has been confirmed to cause severe neurotoxicity, it is urgent to
disclose the underlying toxicity mechanisms at varying levels. TCS exposure resulted in a …

Proteomics Studies Suggest That Nitric Oxide Donor Furoxans Inhibit In Vitro Vascular Smooth Muscle Cell Proliferation by Nitric Oxide-Independent Mechanisms

L Lazzarato, L Bianchi, A Andolfo, A Granata… - Molecules, 2023 - mdpi.com
Physiologically, smooth muscle cells (SMC) and nitric oxide (NO) produced by endothelial
cells strictly cooperate to maintain vasal homeostasis. In atherosclerosis, where this …