Selective luteinizing hormone deficiency due to mutations in the luteinizing hormone beta-
subunit gene (LHB) is a rare cause of hypogonadism. We describe the clinical features of a …

Many scientific studies have revealed a trend towards an earlier onset of puberty and have
disclosed an increasing number of children that display precocious puberty. As an …

Context: CHARGE (coloboma, heart defect, choanal atresia, retarded growth and
development, g enital hypoplasia, ear abnormalities, and/or hearing loss defect) syndrome …

Sweet preference is higher in childhood than adulthood but the mechanism for this
developmental shift is not known. The objective of this study was to assess perceptual …

Precocious puberty in children is one of the common endocrine diseases in paediatrics.
Epidemiological surveys have shown that the number of children with precocious puberty …

Puberty in humans is defined as the period of becoming capable of reproducing. It is marked
by maturation of the genital organs, development of secondary sex characteristics …

Context: Physiological activation of the prokineticin pathway has a critical role in olfactory
bulb morphogenesis and GnRH secretion in mice. Objective: To investigate PROK2 and …

Puberty is the stage of growth leading to sexual maturity and reproductive capacity. In girls,
the initial physical changes are breast development; in boys, testicular growth—both …

Central precocious puberty (CPP) is characterized by early pubertal changes, acceleration
of growth velocity, and rapid bone maturation that often result in reduced adult height. An …

Long-acting GnRH analogs represent the standard treatment for gonadotropin-dependent
precocious puberty. The aim of this study was to determine the hormonal parameters for …