Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies

S Muhammad, T Fan, Y Hai, Y Gao, J He - Molecular Cancer, 2023 - Springer
Abstract Interleukin-2 (IL-2) and its receptor (IL-2R) are essential in orchestrating immune
responses. Their function and expression in the tumor microenvironment make them …

The interplay between immune and metabolic pathways in kidney disease

L Qu, B Jiao - Cells, 2023 - mdpi.com
Kidney disease is a significant health problem worldwide, affecting an estimated 10% of the
global population. Kidney disease encompasses a diverse group of disorders that vary in …

[HTML][HTML] New insights into the role of immunity and inflammation in diabetic kidney disease in the omics era

X Hu, S Chen, S Ye, W Chen, Y Zhou - Frontiers in Immunology, 2024 - frontiersin.org
Diabetic kidney disease (DKD) is becoming the leading cause of chronic kidney disease,
especially in the industrialized world. Despite mounting evidence has demonstrated that …

[HTML][HTML] Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies

T Zhou, YL Fang, TT Tian, GX Wang - World Journal of Diabetes, 2024 - ncbi.nlm.nih.gov
Diabetic kidney disease is one of the most severe chronic microvascular complications of
diabetes and a primary cause of end-stage renal disease. Clinical studies have shown that …

Cross-Domain Text Mining of Pathophysiological Processes Associated with Diabetic Kidney Disease

K Patidar, JH Deng, CS Mitchell… - International Journal of …, 2024 - mdpi.com
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide.
This study's goal was to identify the signaling drivers and pathways that modulate …

The Role of Immune Cells in DKD: Mechanisms and Targeted Therapies

QY Peng, Y An, ZZ Jiang, Y Xu - Journal of Inflammation Research, 2024 - Taylor & Francis
Diabetic kidney disease (DKD), is a common microvascular complication and a major cause
of death in patients with diabetes. Disorders of immune cells and immune cytokines can …

Epigallocatechin-3-gallate maintains Th1/Th2 response balance and mitigates type-1 autoimmune diabetes induced by streptozotocin through promoting the effect of …

F Ahmadzadeh, M Esmaili, SE Enderami, M Ghasemi… - Gene, 2024 - Elsevier
Stem-cell-based therapy is one of the most promising therapeutic strategies owing to its
regenerative and immunomodulatory properties. Epigallocatechin-3-gallate (EGCG), a …

Can immature granulocytes and neutrophil-lymphocyte ratio be biomarkers to evaluate diabetic nephropathy?: A cross-sectional study

F Yay, E Bayram, H Aggul, CÖ Güçlü, D Ayan - Journal of Diabetes and its …, 2024 - Elsevier
Aims We aimed to examine the role of circulating immature granulocytes (IGs) in assessing
Diabetic Nephropathy (DN) mainly and also associations of other leukocyte parameters with …

Perbandingan Terapi Metformin dan Insulin Pada Pasien Chronic Kidney Disease (Ckd)

NRD Pawestri, D Novitasari - Jurnal Ners, 2024 - journal.universitaspahlawan.ac.id
Diabetes adalah kondisi yang umum dan memiliki dampak signifikan pada berbagai sistem
tubuh, dengan sekitar 40% kasus diabetes menjadi lebih rumit dengan Penyakit Ginjal …

The Potential of DC Immunotherapy in Improving Proteinuria in Type 2 Diabetes Mellitus

J Jonny, EC Sitepu, INE Lister, L Chiuman, TA Putranto - 2024 - preprints.org
Abstract Diabetic Kidney Disease (DKD) is a common complication of Type 2 Diabetes
Mellitus and a major risk factor for end-stage kidney disease. The immune system plays a …