A decade of tau transgenic animal models and beyond
The first tau transgenic mouse model was established more than a decade ago. Since then,
much has been learned about the role of tau in Alzheimer's disease and related disorders …
much has been learned about the role of tau in Alzheimer's disease and related disorders …
MicroRNA in pancreatic cancer: pathological, diagnostic and therapeutic implications
MicroRNAs (miRNAs) are a group of small non-coding RNA molecules of 17–25 nucleotides
(nt) in length, predicted to control the activity of about 30% of all protein-coding genes in …
(nt) in length, predicted to control the activity of about 30% of all protein-coding genes in …
Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state
SL Lin, DC Chang, S Chang-Lin, CH Lin, DTS Wu… - Rna, 2008 - rnajournal.cshlp.org
Renewal of stem cells differs from cancer cell growth in self-controlled cell division. The mir-
302 microRNA (miRNA) family (mir-302s) is expressed most abundantly in slow-growing …
302 microRNA (miRNA) family (mir-302s) is expressed most abundantly in slow-growing …
Loss of mir-146a function in hormone-refractory prostate cancer
SL Lin, A Chiang, D Chang, SY Ying - Rna, 2008 - rnajournal.cshlp.org
The pattern of microRNA (miRNA) expression is associated with the degree of tumor cell
differentiation in human prostate cancer. MiRNAs bind complementarily to either oncogenes …
differentiation in human prostate cancer. MiRNAs bind complementarily to either oncogenes …
MicroRNA miR-302 inhibits the tumorigenecity of human pluripotent stem cells by coordinate suppression of the CDK2 and CDK4/6 cell cycle pathways
SL Lin, DC Chang, SY Ying, D Leu, DTS Wu - Cancer research, 2010 - AACR
Abstract miR-302 is the major microRNA found in human embryonic stem cells and induced
pluripotent stem cells, but its function has been unclear. In mice, there is evidence that miR …
pluripotent stem cells, but its function has been unclear. In mice, there is evidence that miR …
Loss of epigenetic silencing in tumors preferentially affects primate-specific retroelements
Close to 50% of the human genome harbors repetitive sequences originally derived from
mobile DNA elements, and in normal cells, this sequence compartment is tightly regulated …
mobile DNA elements, and in normal cells, this sequence compartment is tightly regulated …
[HTML][HTML] A simplified system for the effective expression and delivery of functional mature microRNAs in mammalian cells
J Fan, Y Feng, R Zhang, W Zhang, Y Shu, Z Zeng… - Cancer gene …, 2020 - nature.com
Abstract MicroRNAs (miRNAs) are~ 22 nucleotide noncoding RNAs that are involved in
virtually all aspects of cellular process as their deregulations are associated with many …
virtually all aspects of cellular process as their deregulations are associated with many …
Developmental insights into the pathology of and therapeutic strategies for DM1: Back to the basics
A Chau, A Kalsotra - Developmental Dynamics, 2015 - Wiley Online Library
ABSTRACT Myotonic Dystrophy type 1 (DM1), the most prevalent adult onset muscular
dystrophy, is a trinucleotide repeat expansion disease caused by CTG expansion in the 3 …
dystrophy, is a trinucleotide repeat expansion disease caused by CTG expansion in the 3 …
Deregulation of miR-93 and miR-143 in human esophageal cancer
Esophageal squamous cell carcinoma (ESCC) is the second and third most common
malignancy in Iranian males and females, respectively. Treatment of ESCC is largely …
malignancy in Iranian males and females, respectively. Treatment of ESCC is largely …
[HTML][HTML] LOX-1 and its splice variants: a new challenge for atherosclerosis and cancer-targeted therapies
B Rizzacasa, E Morini, S Pucci, M Murdocca… - International Journal of …, 2017 - mdpi.com
Alternative splicing (AS) is a process in which precursor messenger RNA (pre-mRNA)
splicing sites are differentially selected to diversify the protein isoform population. Changes …
splicing sites are differentially selected to diversify the protein isoform population. Changes …