Architectural proteins are essential epigenetic regulators that play a critical role in
organizing chromatin and controlling gene expression. CTCF (CCCTC-binding factor) is a …

There is increasing evidence indicating the significant role of DDX5 (also called p68), acting
as a master regulator and a potential biomarker and target, in tumorigenesis, proliferation …

Triple-negative breast cancer (TNBC) is a great detriment to women's health due to the lack
of effective therapeutic targets. In this study, we employed an integrated genetic screen to …

DEAD-and DExH-box ATPases (DDX/DHXs) are abundant and highly conserved cellular
enzymes ubiquitously involved in RNA processing. By remodeling RNA–RNA and RNA …

Abstract Forkhead box M1 (FOXM1), a vital member of the Forkhead box family of
transcription factors, helps in mediating oncogenesis. However, limited knowledge exists …

Highlights•• TDP-43 pathology cannot be explained only by gene mutations.•• Domain-
specific protein interaction network begin to reveal the canonical pathways.•• Location of …

Introduction: We have previously shown that the novel positive allosteric modulator of the
GABAA receptor, HK4, exerts hepatoprotective effects against lipotoxicity-induced apoptosis …

Abstract DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with
transcriptional cofactor activity. Although DDX17 is abundantly expressed in the …

Osteosarcoma is a highly metastatic malignant bone tumor, necessitating the development
of new treatments to target its metastasis. Recent studies have revealed the significance of …

Characterizing the profiles of proteome and metabolome at the single-cell level is of great
significance in single-cell multiomic studies. Herein, we proposed a novel strategy called …