Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …

Motivational processes are complex and multifaceted, with both directional and activational
aspects. Behavioral activation and exertion of effort are functions that enable organisms to …

People with depression and other neuropsychiatric disorders can experience motivational
dysfunctions such as fatigue and anergia, which involve reduced exertion of effort in goal …

In order to develop effective treatments for anhedonia we need to understand its underlying
neurobiological mechanisms. Anhedonia is conceptually strongly linked to reward …

Background Anhedonia, as one of the core manifestations of major depressive disorder
(MDD), has an effect on prognosis of the disease. However, the neuropathology of MDD is …

The NIMH research domain criteria (RDoC) approach was instigated to refocus mental
health research on the neural circuits that mediate psychological functions, with the idea that …

Idiopathic rapid eye movement sleep behaviour disorder (iRBD) has now been established
as an important marker of the prodromal stage of Parkinson's disease and related …

Anhedonia is a prevalent symptom across many psychiatric disorders. The contemporary
scope of anhedonia across various models includes interest, reward anticipation, motivation …

Animal models of depression show that acute stress negatively impacts functioning in neural
regions sensitive to reward and punishment, often manifesting as anhedonic behaviors …

Anhedonia is a reduction in enjoyment, motivation, or interest. It is common across mental
health disorders and a harbinger of poor treatment outcomes. The enjoyment aspect, termed …